- Top of page
- 2Cell growth and division: the E. coli life cycle
- 3Transcriptional control of the mra cluster: a plethora of promoters
- 4Cranking the speed: gearboxes and growth rate independence
- 5Beyond mRNA: processing and post-transcriptional controls
- 6Protein regulators of mra transcription
- 7Concluding remarks
Duplication of the Escherichia coli bacterial cell culminates in the formation of a division septum that splits the progenitor cell into two identical daughter cells. Invagination of the cell envelope is brought about by the co-ordinated interplay of a family of septation-specific proteins that act locally at mid-cell at a specific time in the cell cycle. The majority of the genes known to be required for septum formation are found within the large mra cluster located at 2 min on the E. coli genetic map (nucleotides 89 552–107 474). Examination of the controls exerted on the mra operon shows that E. coli uses an extraordinary range of strategies to co-ordinate the expression of the cell division genes with respect to each other and to the cell cycle.