Role played by the response regulator Ris in Bordetella bronchiseptica resistance to macrophage killing

Authors

  • Katarzyna Zimna,

    1. Division of Microbiology, GBF-German Research Centre for Biotechnology, Mascheroder Weg 1, D-38124 Braunschweig, Germany
    2. Department of Molecular Virology, A. Mickiewicz University, Poznan, Poland
    Search for more papers by this author
  • Eva Medina,

    1. Division of Microbiology, GBF-German Research Centre for Biotechnology, Mascheroder Weg 1, D-38124 Braunschweig, Germany
    Search for more papers by this author
  • Heidrun Jungnitz,

    1. Division of Microbiology, GBF-German Research Centre for Biotechnology, Mascheroder Weg 1, D-38124 Braunschweig, Germany
    Search for more papers by this author
  • Carlos A. Guzmán

    Corresponding author
    1. Division of Microbiology, GBF-German Research Centre for Biotechnology, Mascheroder Weg 1, D-38124 Braunschweig, Germany
      *Corresponding author. Tel.: +49 (531) 6181558; Fax: +49 (531) 6181411, E-mail: cag@gbf.de
    Search for more papers by this author

*Corresponding author. Tel.: +49 (531) 6181558; Fax: +49 (531) 6181411, E-mail: cag@gbf.de

Abstract

Previous studies suggested that the persistence in eukaryotic cells of a Bordetella bronchiseptica mutant carrying an insertion in the locus encoding the response regulator RisAS is impaired. This suggested that ris-dependent products are required for the intracellular survival of bacteria. In this study we demonstrate that ris-regulated products play a role in B. bronchiseptica resistance against both phagosomal acidification and reactive oxygen intermediates.

Ancillary