1Department of Cellular and Molecular Physiology, Pennsylvania State University, Milton S. Hershey Medical Centre, Hershey, PA 17033, USA.
Synthesis of six novel N,N-dialkyl derivatives of spermidine and effects on growth of the fungal plant pathogen Pyrenophora avenae
Article first published online: 9 JAN 2006
FEMS Microbiology Letters
Volume 202, Issue 2, pages 221–225, August 2001
How to Cite
Mackintosh, C.A., Slater, L.A., Walters, D.R. and Robins, D.J. (2001), Synthesis of six novel N,N-dialkyl derivatives of spermidine and effects on growth of the fungal plant pathogen Pyrenophora avenae. FEMS Microbiology Letters, 202: 221–225. doi: 10.1111/j.1574-6968.2001.tb10807.x
- Issue published online: 9 JAN 2006
- Article first published online: 9 JAN 2006
- Received 16 May 2001, Revised 28 June 2001, Accepted 1 July 2001
- Spermidine analogue;
- Antifungal activity;
- Pyrenophora avenae
Six novel N,N-dialkyl derivatives of spermidine were synthesised and examined for activity against the oat stripe pathogen Pyrenophora avenae. Two of these spermidine analogues, N,N-dimethyl-N1-(3-aminopropyl)-1,3-diaminopropane trihydrochloride (27) and N,N-dimethyl-N1-(3-aminopropyl)-1,4-diaminobutane trihydrochloride (28), reduced radial extension of P. avenae on plates when used at 2 mM, and caused more substantial reductions in fungal growth in liquid culture when used at 1 mM. Preliminary data suggest that neither compound affected polyamine biosynthesis, determined by following the incorporation of label from ornithine into polyamines and examining intracellular polyamine concentrations in fungal tissue.