Role of membranes in the activities of antimicrobial cationic peptides

Authors

  • Robert E.W. Hancock,

    Corresponding author
    1. Department of Microbiology and Immunology, University of British Columbia, 300–6174 University Blvd, Vancouver, BC, Canada V6T 1Z3
    Search for more papers by this author
  • Annett Rozek

    1. Department of Microbiology and Immunology, University of British Columbia, 300–6174 University Blvd, Vancouver, BC, Canada V6T 1Z3
    Search for more papers by this author

*Corresponding author. Tel.: +1-(604) 822 2682; Fax: +1-(604) 822 6041, E-mail: bob@cmdr.ubc.ca

Abstract

Cationic amphiphilic peptides that are found throughout nature have very broad-spectrum activities against microbes. The initial sites of interaction are with microbial membranes. Although dogma suggests that their lethal action involves disruption of the cytoplasmic membranes, a number of cationic peptides can traverse intact membranes to interact with internal targets.

Ancillary