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- 2Antimicrobial and other activities
- 3Concentration is important
- 4Interaction with model membranes
- 5Interaction with intact bacteria
- 6Modes of action
Cationic amphiphilic peptides that are found throughout nature have very broad-spectrum activities against microbes. The initial sites of interaction are with microbial membranes. Although dogma suggests that their lethal action involves disruption of the cytoplasmic membranes, a number of cationic peptides can traverse intact membranes to interact with internal targets.