• [1]
    Lyczak, J.B., Cannon, C.L., Pier, G.B. (2000) Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist. Microb. Infect. 9, 10511060.
  • [2]
    Fleiszig, S.M.J., Zaidi, T.S., Fletcher, E.L., Preston, M.J., Pier, G.B. (1994) Pseudomonas aeruginosa invades corneal epithelial cells during experimental infection. Infect. Immun. 62, 34853492.
  • [3]
    Plotkowski, M.C., Saliba, A.M., Pereira, S.H., Cervante, M.P., Bajolet-Laudinat, O. (1994) Pseudomonas aeruginosa selective adherence to and entry into human endothelial cells. Infect. Immun. 62, 54565463.
  • [4]
    Fleiszig, S.M.J., Zaidi, T.S., Pier, G.B. (1995) Pseudomonas aeruginosa survival and multiplication within corneal epithelial cells in vitro. Infect. Immun. 63, 40724077.
  • [5]
    Pier, G.B., Grout, M., Zaidi, T.S., Olsen, J.C., Johnson, L.G., Yankaskas, J.R., Goldberg, J.B. (1996) Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections. Science 271, 6467.
  • [6]
    Zaidi, T.S., Fleiszig, S.M.J., Preston, M.J., Goldberg, J.B., Pier, G.B. (1996) Lipopolysaccharide outer core is a ligand for corneal cell binding and ingestion of Pseudomonas aeruginosa. Invest. Ophthalmol. Vis. Sci. 37, 976986.
  • [7]
    Evans, D.J., Kuo, T.C., Van, R., Fleiszig, S.M.J. The role of lipopolysaccharide in Pseudomonas aeruginosa corneal epithelial cell invasion includes intracellular survival. Invest. Ophthalmol. Vis. Sci. 41, (2000) S153
  • [8]
    Comolli, J.C., Waite, L.L., Mostov, K.E., Engel, J.N. (1999) Pili binding to asialo-GM1 on epithelial cells can mediate cytotoxicity or bacterial internalization by Pseudomonas aeruginosa. Infect. Immun. 67, 32073214.
  • [9]
    Fleiszig, S.M.J., Arora, S.K., Van, R., Ramphal, R. (2001) FlhA, a component of the flagellar assembly apparatus of Pseudomonas aeruginosa, plays a role in internalization by corneal epithelial cells. Infect. Immun. 69, 49314937.
  • [10]
    Evans, D.J., Frank, D.W., Finck-Barbançon, V., Wu, C., Fleiszig, S.M.J. (1998) Pseudomonas aeruginosa invasion and cytotoxicity are independent events, both of which involve protein tyrosine kinase activity. Infect. Immun. 66, 14531459.
  • [11]
    Esen, M., Grassmé, H., Riethmüller, J., Riehle, A., Fassbender, K., Gulbins, E. (2001) Invasion of human epithelial cells by Pseudomonas aeruginosa involves Src-like tyrosine kinases p60Src and p59Fyn. Infect. Immun. 69, 281287.
  • [12]
    Kazmierczak, B.I., Jou, T.S., Mostov, K.E., Engel, J.N. (2001) Rho GTPase activity modulates Pseudomonas aeruginosa internalization by epithelial cells. Cell. Microbiol. 3, 8598.
  • [13]
    Davis, R.J. (1993) The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem. 268, 1455314556.
  • [14]
    Robinson, M.J., Cobb, M.H. (1997) Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol. 9, 180186.
  • [15]
    Tang, P., Sutherland, C.L., Gold, M.R., Finlay, B.B. (1998) Listeria monocytogenes invasion of epithelial cells requires the MEK-1/ERK-2 mitogen activated protein kinase pathway. Infect. Immun. 66, 11061112.
  • [16]
    Ellington, J.K., Elhofy, A., Bost, K.L., Hudson, M.C. (2001) Involvement of mitogen-activated protein kinase pathways in Staphylococcus aureus invasion of normal osteoblasts. Infect. Immun. 69, 52355242.
  • [17]
    Watanabe, K., Yilmaz, O., Nakhjiri, S.F., Belton, C.M., Lamont, R.J. (2001) Association of mitogen-activated protein kinase pathways with gingival epithelial cell responses to Porphyromonas gingivalis infection. Infect. Immun. 69, 67316737.
  • [18]
    Kohler, H., Rodrigues, S.P., McCormick, B.A. (2002) Shigella flexneri interactions with the basolateral membrane domain of polarized model intestinal epithelium: Role of lipopolysaccharide in cell invasion and in activation of the mitogen-activated protein kinase ERK. Infect. Immun. 70, 11501158.
  • [19]
    Clark, M.A., Brugge, J.S. (1995) Integrins and signal transduction pathways: The road taken. Science 268, 233239.
  • [20]
    Fincham, V.J., James, M., Frame, M.C., Winder, S.J. (2000) Active ERK/MAP kinase is targeted to newly forming cell–matrix adhesions by integrin engagement and v-Src. EMBO J. 19, 29112923.
  • [21]
    Schlaepfer, D.D., Hunter, T. (1997) Focal adhesion kinase overexpression enhances Ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src. J. Biol. Chem. 272, 1318913195.
  • [22]
    Ratner, A.J., Bryan, R., Weber, A., Nguyen, S., Barnes, D., Pitt, A., Gelber, S., Cheung, A., Prince, A. (2001) Cystic fibrosis pathogens activate Ca2+-dependent mitogen-activated protein kinase signaling pathways in airway epithelial cells. J. Biol. Chem. 276, 1926719275.
  • [23]
    Okamoto, S., Oji, M., Hassell, J.R., Thoft, R.A., Pipas, J.M. Establishment of an immortalized rabbit corneal epithelial cell line using SV40 large T antigen. Invest. Ophthalmol. Vis. Sci. 34, (1993) S1010
  • [24]
    Jumblatt, M.M., Neufeld, A.H. (1983) β-adrenergic and serotonergic responsiveness of rabbit corneal epithelial cells in culture. Invest. Ophthalmol. Vis. Sci. 24, 11391143.
  • [25]
    Fox, T., Coll, J.T., Xie, X., Ford, P.J., Germann, U.A., Porter, M.D., Pazhanisamy, S., Fleming, M.A., Galullo, V., Su, M.S.S., Wilson, K.P. (1998) A single amino acid substitution makes ERK 2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase. Protein Sci. 7, 22492255.
  • [26]
    Zheng, C.F., Guan, K.L. (1993) Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases. J. Biol. Chem. 268, 2393323939.
  • [27]
    Procyk, K.J., Kovarik, P., von Gabain, A., Baccarini, M. (1999) Salmonella typhimurium and lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving phosphatidylinositol 3-kinase and phospholipase D as novel intermediates. Infect. Immun. 67, 10111017.
  • [28]
    Alessi, D.R., Cuenda, A., Cohen, P., Dudley, D.T., Saltiel, A.R. (1995) PD98059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270, 2748927494.
  • [29]
    Dudley, D.T., Pang, L., Decker, S.J., Bridges, A.J., Saltiel, A.R. (1995) A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA 92, 76867689.
  • [30]
    Favata, M.F., Horiuchi, K.Y., Manos, E.J., Daulerio, A.J., Stradley, D.A., Feeser, W.S., van Dyk, D.E., Pitts, W.J., Earl, R.A., Hobbs, F., Copeland, R.A., Magolda, R.L., Scherle, P.A., Trzaskos, J.M. (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J. Biol. Chem. 273, 1862318632.
  • [31]
    Bliska, J.B., Galán, J.E., Falkow, S. (1993) Signal transduction in the mammalian cell during bacterial attachment and entry. Cell 73, 903920.
  • [32]
    Liu, M.K., Herrera-Velit, P., Brownsey, R.W., Reiner, N.E. (1994) CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide. J. Immunol. 153, 26422652.
  • [33]
    Buscher, D., Hipskind, R.A., Krautwald, S., Reimann, T., Baccarini, M. (1995) Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages. Mol. Cell. Biol. 15, 466475.
  • [34]
    Li, J.D., Feng, W., Gallup, M., Kim, J.H., Gum, J., Kim, Y., Basbaum, C. (1998) Activation of NF-kappaB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells. Proc. Natl. Acad. Sci. USA 95, 57185723.
  • [35]
    McNamara, N.A., Khong, A., McKemy, D., Caterina, M., Boyer, J., Julius, D., Basbaum, C. (2001) ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor. Proc. Natl. Acad. Sci. USA 98, 90869091.