Department of Microbiology, University College Cork, Western Road, Cork, Ireland.
The Bacillus subtilis transition state regulator AbrB binds to the −35 promoter region of comK
Article first published online: 9 JAN 2006
FEMS Microbiology Letters
Volume 218, Issue 2, pages 299–304, January 2003
How to Cite
Hamoen, L. W., Kausche, D., Marahiel, M. A., van Sinderen, D., Venema, G. and Serror, P. (2003), The Bacillus subtilis transition state regulator AbrB binds to the −35 promoter region of comK. FEMS Microbiology Letters, 218: 299–304. doi: 10.1111/j.1574-6968.2003.tb11532.x
- Issue published online: 9 JAN 2006
- Article first published online: 9 JAN 2006
- Received 30 October 2002, Accepted 18 November 2002
Genetic competence is a differentiation process initiated by Bacillus subtilis as a result of nutritional deprivation, and is controlled by a complex signal transduction cascade. The promoter of comK, encoding the competence transcription factor, is regulated by at least four different transcription factors: Rok, CodY, DegU and ComK itself. Genetic data have shown that comK expression is influenced by the transition state regulator AbrB as well. In this paper we show that AbrB binds specifically to the comK promoter and covers the RNA polymerase binding site, making it the fifth transcription factor regulating the activity of the comK promoter.