Editor: Stephen Smith
An intragenic deletion in pilQ leads to nonpiliation of a Pseudomonas aeruginosa strain isolated from cystic fibrosis lung
Version of Record online: 16 FEB 2007
FEMS Microbiology Letters
Volume 270, Issue 2, pages 201–206, May 2007
How to Cite
Chang, Y.-S. T., Klockgether, J. and Tümmler, B. (2007), An intragenic deletion in pilQ leads to nonpiliation of a Pseudomonas aeruginosa strain isolated from cystic fibrosis lung. FEMS Microbiology Letters, 270: 201–206. doi: 10.1111/j.1574-6968.2007.00664.x
- Issue online: 16 FEB 2007
- Version of Record online: 16 FEB 2007
- Received 1 December 2006; revised 16 January 2007; accepted 16 January 2007.First published online 15 February 2007.
- cystic fibrosis;
- Pseudomonas aeruginosa;
- type IV pili;
Deficient motility is one of the characteristic hallmarks observed in Pseudomonas aeruginosa strains that chronically colonize the lungs of cystic fibrosis (CF) patients. Pseudomonas aeruginosa TB is a nonpiliated CF isolate known to be defective in twitching motility. Complementation confirmed a direct link of this phenotype to an intragenic out-of-frame deletion in pilQ (PA5040). Sequence alignment of pilQ derived from TB vs. PAO1 suggests that close direct repeats framing the deletion site may have triggered this mutation. This type of mutation could play a role in the emergence of pathoadaptive mutations of P. aeruginosa in the CF lung habitat.