You have full text access to this OnlineOpen article

Glanders: off to the races with Burkholderia mallei

  1. Gregory C. Whitlock1,
  2. D. Mark Estes1,2,3,
  3. Alfredo G. Torres1,3,4

Article first published online: 26 OCT 2007

DOI: 10.1111/j.1574-6968.2007.00949.x

Issue

FEMS Microbiology Letters

FEMS Microbiology Letters

Volume 277, Issue 2, pages 115–122, December 2007

Additional Information

How to Cite

Whitlock, G. C., Mark Estes, D. and Torres, A. G. (2007), Glanders: off to the races with Burkholderia mallei. FEMS Microbiology Letters, 277: 115–122. doi: 10.1111/j.1574-6968.2007.00949.x

Author Information

  1. 1

    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA

  2. 2

    Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA

  3. 3

    Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX, USA; and

  4. 4

    Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA

*Correspondence: Alfredo G. Torres, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-1070, USA. Tel.: +00 1 409 747 0189; fax: +00 1 409 747 6869; e-mail: altorres@utmb.edu

Publication History

  1. Issue published online: 26 OCT 2007
  2. Article first published online: 26 OCT 2007
  3. Received 13 August 2007; accepted 14 September 2007.First published online 26 October 2007.

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (231K)

Keywords:

  • Burkholderia;
  • Burkholderia mallei;
  • glanders;
  • virulence factors;
  • immune responses

Abstract

Burkholderia mallei, the etiologic agent of the disease known as glanders, is primarily a disease affecting horses and is transmitted to humans by direct contact with infected animals. The use of B. mallei as a biological weapon has been reported and currently, there is no vaccine available for either humans or animals. Despite the history and highly infective nature of B. mallei, as well as its potential use as a bio-weapon, B. mallei research to understand the pathogenesis and the host responses to infection remains limited. Therefore, this minireview will focus on current efforts to elucidate B. mallei virulence, the associated host immune responses elicited during infection and discuss the feasibility of vaccine development.

View Full Article (HTML) Get PDF (231K)