Editor: Julian Ketley
Regulation of magnesium homeostasis in Salmonella: Mg2+ targets the mgtA transcript for degradation by RNase E
Article first published online: 4 FEB 2008
© 2008 Federation of European Microbiological Societies
FEMS Microbiology Letters
Volume 280, Issue 2, pages 226–234, March 2008
How to Cite
Spinelli, S. V., Pontel, L. B., García Véscovi, E. and Soncini, F. C. (2008), Regulation of magnesium homeostasis in Salmonella: Mg2+ targets the mgtA transcript for degradation by RNase E. FEMS Microbiology Letters, 280: 226–234. doi: 10.1111/j.1574-6968.2008.01065.x
- Issue published online: 4 FEB 2008
- Article first published online: 4 FEB 2008
- Received 29 August 2007; accepted 19 December 2007.First published online 4 February 2008.
- Mg2+ homeostasis;
- transcriptional regulation;
- RNase E;
Extracellular Mg2+ controls the activation of the Salmonella PhoP/PhoQ regulatory system. One of the adaptive responses driven by PhoP/PhoQ includes the transcriptional induction of mgtA and mgtCB, which encode two P-type Mg2+ transporters. Mg2+ also controls mgtA expression by a riboswitch located in its 5′-untranslated region (5′UTR). In this work, it was shown that the 5′UTR of both mgtA and mgtCB is responsible for a fine-tuned Mg2+-dependent regulation of these genes. Evidence was also provided that the Mg2+ riboswitch targets the mgtA transcript for degradation by RNase E when cells are grown in high Mg2+ environments.