Editor: Simon Silver
Quorum sensing in metal tolerance of Acinetobacter junii BB1A is associated with biofilm production
Article first published online: 4 APR 2008
© 2008 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved
FEMS Microbiology Letters
Volume 282, Issue 2, pages 160–165, May 2008
How to Cite
Sarkar, S. and Chakraborty, R. (2008), Quorum sensing in metal tolerance of Acinetobacter junii BB1A is associated with biofilm production. FEMS Microbiology Letters, 282: 160–165. doi: 10.1111/j.1574-6968.2008.01080.x
- Issue published online: 4 APR 2008
- Article first published online: 4 APR 2008
- Received 4 August 2007; accepted 3 January 2008.First published online 4 April 2008.
- metal tolerance;
- quorum sensing;
- Acinetobacter junii
Acinetobacter junii strain BB1A, a novel metal-tolerant bacterium, produced biofilm in the presence of added ions such as Ni2+, AsO2−, Cd2+ and Hg2+ on surfaces such as glass and polystyrene. Generation of a metal-sensitive and adhesion-deficient mutant by transposition of Tn5-mob in the A. junii genome has putatively confirmed the association of metal tolerance with the production of biofilm. The requirement of a critical cell density for biofilm formation and presence of acyl-homoserine lactone-like autoinducer molecules in the cell-free supernatant indicated the phenomenon of quorum sensing. Addition of a natural quorum-sensing inhibitor (garlic extract) or synthetic quorum-sensing inhibitor (4-nitro-pyridine oxide) significantly inhibited cell growth and biofilm formation in the presence of metal/metalloid ions.