Editor: Wolfgang Kneifel
Specific probiotic strains and their combinations counteract adhesion of Enterobacter sakazakii to intestinal mucus
Article first published online: 23 MAY 2008
© 2008 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved
FEMS Microbiology Letters
Volume 285, Issue 1, pages 58–64, August 2008
How to Cite
Collado, M. C., Isolauri, E. and Salminen, S. (2008), Specific probiotic strains and their combinations counteract adhesion of Enterobacter sakazakii to intestinal mucus. FEMS Microbiology Letters, 285: 58–64. doi: 10.1111/j.1574-6968.2008.01211.x
- Issue published online: 8 JUL 2008
- Article first published online: 23 MAY 2008
- Received 26 November 2007; accepted 21 April 2008.First published online 23 May 2008.
- probiotic combination;
- Enterobacter sakazakii
Enterobacter sakazakii is an opportunistic pathogen and an occasional contaminant in powdered infant formula. Interaction between specific probiotics and E. sakazakii may reduce the risk of infection. The aim of this study was to characterize in vitro the ability of probiotics (alone and in combinations) to inhibit, compete with and displace the adhesion of E. sakazakii to immobilized human mucus and to assess their capacity to aggregate with pathogen. Specific probiotic strains have proved to aggregate E. sakazakii cells and, through competitive exclusion, inhibition and displacement of the adhered pathogen, were able to inhibit E. sakazakii action on intestinal mucus. The ability to inhibit and to displace adhered pathogen depended on both the probiotic and the pathogen, suggesting that several complementary mechanisms are involved in the processes. We suggest that the selection of specific probiotic strains and their combinations may be a useful means of counteracting E. sakazakii contamination in infant formula and thus to reduce the risk of emerging infection. This approach may also allow the development of new probiotic combinations to counteract the risks associated with other pathogens by improving the intestinal barrier against pathogens.