Editor: Ezio Ricca
The Escherichia coli FtsK functional domains involved in its interaction with its divisome protein partners
Article first published online: 28 AUG 2008
Journal compilation © 2008 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. No claim to original Italian government works
FEMS Microbiology Letters
Volume 287, Issue 2, pages 163–167, October 2008
How to Cite
Grenga, L., Luzi, G., Paolozzi, L. and Ghelardini, P. (2008), The Escherichia coli FtsK functional domains involved in its interaction with its divisome protein partners. FEMS Microbiology Letters, 287: 163–167. doi: 10.1111/j.1574-6968.2008.01317.x
- Issue published online: 9 SEP 2008
- Article first published online: 28 AUG 2008
- Received 9 June 2008; accepted 14 July 2008.First published online 28 August 2008.
- protein–protein interaction;
- bacterial cell division;
- two-hybrid assay;
- fts genes
FtsK is a multifunctional protein involved in both cell division and chromosome segregation. As far as its role in cell division is concerned, FtsK is among the first divisome proteins that localizes at mid-cell, after FtsZ, FtsA and ZipA, and is required for the recruitment of the other divisome components. The ability of FtsK to interact with several cell division proteins, namely FtsZ, FtsQ, FtsL and FtsI, by the two-hybrid assay was already shown by our group. In this work, we describe the identification of the protein domain(s) involved in the interaction with the cell division partner proteins. The biological role of some interactions is also discussed.