Editor: Geoffrey Gadd
10-Undecanhydroxamic acid, a hydroxamate derivative of the undecanoic acid, has strong antimicrobial activity through a mechanism that limits iron availability
Article first published online: 18 MAR 2009
© 2009 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved
FEMS Microbiology Letters
Volume 294, Issue 1, pages 61–67, May 2009
How to Cite
Ammendola, S., Lembo, A., Battistoni, A., Tagliatesta, P., Ghisalberti, C. and Desideri, A. (2009), 10-Undecanhydroxamic acid, a hydroxamate derivative of the undecanoic acid, has strong antimicrobial activity through a mechanism that limits iron availability. FEMS Microbiology Letters, 294: 61–67. doi: 10.1111/j.1574-6968.2009.01537.x
- Issue published online: 2 APR 2009
- Article first published online: 18 MAR 2009
- Received 21 October 2008; accepted 3 February 2009.First published online 18 March 2009.
- undecanoic acid;
- iron homeostasis;
Undecanoic acid (UDA) is a fatty acid with significant antimycotic activity. In this work we have synthesized 10-undecanhydroxamic acid, a hydroxamate derivative of the UDA, and tested its antimicrobial activity on different microorganisms. Our results demonstrate that this compound has higher efficacy than UDA against a variety of fungi and bacteria. Analysis of the intracellular concentration of protein involved in iron transport in Salmonella enterica serovar Typhimurium suggests that its antimicrobial effect actually relies on the ability to chelate iron ions, providing an efficient mechanism to interfere with microbial growth.