Editor: Jeff Cole
A pivotal role for the Streptococcus iniae extracellular polysaccharide in triggering proinflammatory cytokines transcription and inducing death in rainbow trout
Article first published online: 3 FEB 2010
© 2010 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved
FEMS Microbiology Letters
Volume 305, Issue 2, pages 109–120, April 2010
How to Cite
Eyngor, M., Lublin, A., Shapira, R., Hurvitz, A., Zlotkin, A., Tekoah, Y. and Eldar, A. (2010), A pivotal role for the Streptococcus iniae extracellular polysaccharide in triggering proinflammatory cytokines transcription and inducing death in rainbow trout. FEMS Microbiology Letters, 305: 109–120. doi: 10.1111/j.1574-6968.2010.01919.x
- Issue published online: 16 MAR 2010
- Article first published online: 3 FEB 2010
- Received 7 December 2009; accepted 1 January 2010.Final version published online 1 March 2010.
- Streptococcus iniae;
- extracellular polysaccharide;
Streptococcus iniae is a major pathogen of fish, causing considerable economic losses in Israel, the United States and the Far East. Containment of mortalities through vaccination was recently compromised due to the emergence of novel vaccine-escape strains that are distinguished from previous strains by their ability to produce large amounts of extracellular polysaccharide (EPS) that is released to the medium. In vitro and in vivo data now indicate that the EPS is a major virulence factor, capable of triggering the proinflammatory cytokine machinery and inducing mortality of fish. Streptococcus iniae EPS might therefore be considered to be responsible for sepsis and death just as lipopolysaccharide is for Gram-negative pathogens.