Editor: Derek Sullivan
From Saccharomyces cerevisiae to Candida glabrata in a few easy steps: important adaptations for an opportunistic pathogen
Article first published online: 16 SEP 2010
© 2010 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved
FEMS Microbiology Letters
Volume 314, Issue 1, pages 1–9, January 2011
How to Cite
Roetzer, A., Gabaldón, T. and Schüller, C. (2011), From Saccharomyces cerevisiae to Candida glabrata in a few easy steps: important adaptations for an opportunistic pathogen. FEMS Microbiology Letters, 314: 1–9. doi: 10.1111/j.1574-6968.2010.02102.x
- Issue published online: 3 DEC 2010
- Article first published online: 16 SEP 2010
- Accepted manuscript online: 25 AUG 2010 08:36AM EST
- Received 6 June 2010; revised 18 August 2010; accepted 19 August 2010.Final version published online 16 September 2010.
- fungal pathogen;
- stress response;
The opportunistic human fungal pathogen Candida glabrata is closely related to Saccharomyces cerevisiae, yet it has evolved to survive within mammalian hosts. Which traits help C. glabrata to adapt to this different environment? Which specific responses are crucial for its survival in the host? The main differences seem to include an extended repertoire of adhesin genes, high drug resistance, an enhanced ability to sustain prolonged starvation and adaptations of the transcriptional wiring of key stress response genes. Here, we discuss the properties of C. glabrata with a focus on the differences to related fungi.