Editor: Derek Sullivan
The contribution of mouse models to our understanding of systemic candidiasis
Version of Record online: 24 MAR 2011
© 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved
FEMS Microbiology Letters
Volume 320, Issue 1, pages 1–8, July 2011
How to Cite
Szabo, E. K. and MacCallum, D. M. (2011), The contribution of mouse models to our understanding of systemic candidiasis. FEMS Microbiology Letters, 320: 1–8. doi: 10.1111/j.1574-6968.2011.02262.x
- Issue online: 1 JUN 2011
- Version of Record online: 24 MAR 2011
- Accepted manuscript online: 11 MAR 2011 01:59PM EST
- Received 8 February 2011; revised 4 March 2011; accepted 4 March 2011., Final version published online 24 March 2011.
- Candida ;
Some Candida species are common commensals, which can become opportunistic pathogens in susceptible hosts. In severely ill patients, Candida species, particularly Candida albicans, can cause life-threatening systemic infections. These infections are difficult to diagnose, as symptoms are similar to those of systemic bacterial infections. These difficulties can lead to delays in initiation in antifungal therapy, which contributes to the high mortality rates (>40%) associated with these infections. In order to investigate systemic Candida infection, mouse models have been developed that mimic human disease, the most common being the intravenous infection model and the gastrointestinal colonization and dissemination model. This review discusses the two models and the contributions that they have made to our understanding of fungal virulence, host response to infection and the development of novel antifungal therapies and diagnostics.