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Keywords:

  • mycobacteria;
  • tuberculosis;
  • DAP biosynthesis;
  • meso-DAP;
  • lysine;
  • peptidoglycan

Abstract

Because of an increased emergence of resistance to current antitubercular drugs, there is a need for new antitubercular agents directed against novel targets. Diaminopimelic acid (DAP) biosynthetic enzymes are unique to bacteria and are absent in mammals and provide a rich source of essential targets for antitubercular chemotherapy. Herein, we review the structure and function of the mycobacterial DAP biosynthetic enzymes.