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  • Antia M, Hoare DS & Work E (1957) The stereoisomers of alpha epsilon-diaminopimelic acid. III. Properties and distribution of diaminopimelic acid racemase, an enzyme causing interconversion of the LL and meso isomers. Biochem J 65: 448459.
  • Badger J, Sauder JM, Adams JM et al. (2005) Structural analysis of a set of proteins resulting from a bacterial genomics project. Proteins 60: 787796.
  • Bienvenue DL, Gilner DM, Davis RS, Bennett B & Holz RC (2003) Substrate specificity, metal binding properties, and spectroscopic characterization of the DapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae. Biochemistry 42: 1075610763.
  • Born TL & Blanchard JS (1999) Structure/function studies on enzymes in the diaminopimelate pathway of bacterial cell wall biosynthesis. Curr Opin Chem Biol 3: 607613.
  • Born TL, Zheng R & Blanchard JS (1998) Hydrolysis of N-succinyl-L,L-diaminopimelic acid by the Haemophilus influenzae dapE-encoded desuccinylase: metal activation, solvent isotope effects, and kinetic mechanism. Biochemistry 37: 1047810487.
  • Bouvier J, Richaud C, Higgins W, Bogler O & Stragier P (1992) Cloning, characterization, and expression of the dapE gene of Escherichia coli. J Bacteriol 174: 52655271.
  • Broder DH & Miller CG (2003) DapE can function as an aspartyl peptidase in the presence of Mn2+. J Bacteriol 185: 47484754.
  • Bzymek KP & Holz RC (2004) The catalytic role of glutamate 151 in the leucine aminopeptidase from Aeromonas proteolytica. J Biol Chem 279: 3101831025.
  • Cirilli M, Zheng R, Scapin G & Blanchard JS (2003) The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity. Biochemistry 42: 1064410650.
  • Cirillo JD, Weisbrod TR, Banerjee A, Bloom BR & Jacobs WR Jr (1994a) Genetic determination of the meso-diaminopimelate biosynthetic pathway of mycobacteria. J Bacteriol 176: 44244429.
  • Cirillo JD, Weisbrod TR, Pascopella L, Bloom BR & Jacobs WR Jr (1994b) Isolation and characterization of the aspartokinase and aspartate semialdehyde dehydrogenase operon from mycobacteria. Mol Microbiol 11: 629639.
  • Corbett L & Raviglione M (2005). Global burden of tuberculosis: past, present and future. Tuberculosis and The Tubercle Bacillus (Cole ST, Eisenach KD, McMurray DN & Jacobs WR Jr), pp. 312. ASM Press, Washington, DC.
  • Cosper NJ, Bienvenue DL, Shokes JE, Gilner DM, Tsukamoto T, Scott RA & Holz RC (2003) The dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae is a dinuclear metallohydrolase. J Am Chem Soc 125: 1465414655.
  • Cox RJ, Sutherland A & Vederas JC (2000) Bacterial diaminopimelate metabolism as a target for antibiotic design. Bioorg Med Chem 8: 843871.
  • Davis R, Bienvenue D, Swierczek SI, Gilner DM, Rajagopal L, Bennett B & Holz RC (2006) Kinetic and spectroscopic characterization of the E134A- and E134D-altered dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae. J Biol Inorg Chem 11: 206216.
  • Diaper CM, Sutherland A, Pillai B, James MN, Semchuk P, Blanchard JS & Vederas JC (2005) The stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their interaction with dap epimerase. Org Biomol Chem 3: 44024411.
  • Dorman SE & Chaisson RE (2007) From magic bullets back to the magic mountain: the rise of extensively drug-resistant tuberculosis. Nat Med 13: 295298.
  • Evans G, Schuldt L, Griffin MD et al. (2011) A tetrameric structure is not essential for activity in dihydrodipicolinate synthase (DHDPS) from Mycobacterium tuberculosis. Arch Biochem Biophys 512: 154159.
  • Frieden TR, Sterling TR, Munsiff SS, Watt CJ & Dye C (2003) Tuberculosis. Lancet 362: 887899.
  • Ghuysen JM (1980). Antibiotics and peptidoglycan metabolism. Topics in Antibiotic Chemistry (PG Sammes, ed), pp. 9117. Wiley and Sons, New York.
  • Gillner D, Armoush N, Holz RC & Becker DP (2009a) Inhibitors of bacterial N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity. Bioorg Med Chem Lett 19: 63506352.
  • Gillner DM, Bienvenue DL, Nocek BP, Joachimiak A, Zachary V, Bennett B & Holz RC (2009b) The dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae contains two active-site histidine residues. J Biol Inorg Chem 14: 110.
  • Girodeau JM, Agouridas C, Masson M, Pineau R & Le Goffic F (1986) The lysine pathway as a target for a new genera of synthetic antibacterial antibiotics? J Med Chem 29: 10231030.
  • Harper C (2007) Tuberculosis, a neglected opportunity? Nat Med 13: 309312.
  • Hudson AO, Bless C, Macedo P, Chatterjee SP, Singh BK, Gilvarg C & Leustek T (2005) Biosynthesis of lysine in plants: evidence for a variant of the known bacterial pathways. Biochim Biophys Acta 1721: 2736.
  • Janowski R, Kefala G & Weiss MS (2009) The structure of dihydrodipicolinate reductase (DapB) from Mycobacterium tuberculosis in three crystal forms. Acta Crystallogr D Biol Crystallogr 66: 6172.
  • Karita M, Etterbeek ML, Forsyth MH, Tummuru MK & Blaser MJ (1997) Characterization of Helicobacter pylori dapE and construction of a conditionally lethal dapE mutant. Infect Immun 65: 41584164.
  • Kefala G & Weiss MS (2006) Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of DapA (Rv2753c) from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 62: 11161119.
  • Kefala G, Janowski R, Panjikar S, Mueller-Dieckmann C & Weiss MS (2005) Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of DapB (Rv2773c) from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 61: 718721.
  • Kefala G, Evans GL, Griffin MD, Devenish SR, Pearce FG, Perugini MA, Gerrard JA, Weiss MS & Dobson RC (2008) Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis. Biochem J 411: 351360.
  • Koo CW & Blanchard JS (1999) Chemical mechanism of Haemophilus influenzae diaminopimelate epimerase. Biochemistry 38: 44164422.
  • Lloyd AJ, Huyton T, Turkenburg J & Roper DI (2004) Refinement of Haemophilus influenzae diaminopimelic acid epimerase (DapF) at 1.75 Å resolution suggests a mechanism for stereocontrol during catalysis. Acta Crystallogr D Biol Crystallogr 60: 397400.
  • Mathema B, Kurepina NE, Bifani PJ & Kreiswirth BN (2006) Molecular epidemiology of tuberculosis: current insights. Clin Microbiol Rev 19: 658685.
  • Matsuhashi M (1994) Utilization of lipid-linked precursors and the formation of peptidoglycan in the process of cell growth and division: membrane enzymes involved in the final steps of peptidoglycan synthesis and the mechanism of their regulation. Bacterial Cell Wall (Ghuysen JM & Hakenbeck R, eds), pp. 5571. Elsevier Science, Amsterdam, the Netherlands.
  • Nocek BP, Gillner DM, Fan Y, Holz RC & Joachimiak A (2010) Structural basis for catalysis by the mono- and dimetalated forms of the dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase. J Mol Biol 397: 617626.
  • Paiva AM, Vanderwall DE, Blanchard JS, Kozarich JW, Williamson JM & Kelly TM (2001) Inhibitors of dihydrodipicolinate reductase, a key enzyme of the diaminopimelate pathway of Mycobacterium tuberculosis. Biochim Biophys Acta 1545: 6777.
  • Pavelka MS Jr (2000). Genetics of mycobacterial metabolism. Molecular Genetics of Mycobacteria (Hatfull GF & Jacobs WR Jr, eds), pp. 221234. ASM Press, Washington, DC.
  • Pavelka MS Jr & Jacobs WR Jr (1996) Biosynthesis of diaminopimelate, the precursor of lysine and a component of peptidoglycan, is an essential function of Mycobacterium smegmatis. J Bacteriol 178: 64966507.
  • Pavelka MS Jr, Weisbrod TR & Jacobs WR Jr (1997) Cloning of the dapB gene, encoding dihydrodipicolinate reductase, from Mycobacterium tuberculosis. J Bacteriol 179: 27772782.
  • Pillai B, Cherney MM, Diaper CM, Sutherland A, Blanchard JS, Vederas JC & James MN (2006) Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target. P Natl Acad Sci USA 103: 86688673.
  • Sassetti CM, Boyd DH & Rubin EJ (2001) Comprehensive identification of conditionally essential genes in mycobacteria. P Natl Acad Sci USA 98: 1271212717.
  • Sassetti CM, Boyd DH & Rubin EJ (2003) Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol 48: 7784.
  • Schleifer KH & Kandler O (1972) Peptidoglycan types of bacterial cell walls and their taxonomic implications. Bacteriol Rev 36: 407477.
  • Schuldt L, Weyand S, Kefala G & Weiss MS (2008) Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of tetrahydrodipicolinate-N-succinyltransferase (Rv1201c) from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 64: 863866.
  • Schuldt L, Weyand S, Kefala G & Weiss MS (2009) The three-dimensional structure of a mycobacterial DapD provides insights into DapD diversity and reveals unexpected particulars about the enzymatic mechanism. J Mol Biol 389: 863879.
  • Schuldt L, Suchowersky R, Veith K, Mueller-Dieckmann J & Weiss MS (2011) Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the regulatory domain of aspartokinase (Rv3709c) from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 67: 380385.
  • Shafiani S, Sharma P, Vohra RM & Tewari R (2005) Cloning and characterization of aspartate-beta-semialdehyde dehydrogenase from Mycobacterium tuberculosis H37 Rv. J Appl Microbiol 98: 832838.
  • Singh A, Kushwaha HR & Sharma P (2008) Molecular modelling and comparative structural account of aspartyl beta-semialdehyde dehydrogenase of Mycobacterium tuberculosis (H37Rv). J Mol Model 14: 249263.
  • Sritharan V, Wheeler PR & Ratledge C (1989) Metabolism of aspartate in Mycobacterium smegmatis. Eur J Biochem 180: 587593.
  • Uda NR & Creus M (2011) Selectivity of Inhibition of N-Succinyl-L,L-diaminopimelic acid desuccinylase in bacteria: the product of dapE-gene is not the target of L-Captopril antimicrobial activity. Bioinorg Chem Appl 2011: 306465.
  • Usha V, Dover LG, Roper DL, Lloyd AJ & Besra GS (2006) Use of a codon alteration strategy in a novel approach to cloning the Mycobacterium tuberculosis diaminopimelic acid epimerase. FEMS Microbiol Lett 262: 3947.
  • Usha V, Dover LG, Roper DL & Besra GS (2008) Characterization of Mycobacterium tuberculosis diaminopimelic acid epimerase: paired cysteine residues are crucial for racemization. FEMS Microbiol Lett 280: 5763.
  • Usha V, Dover LG, Roper DI, Futterer K & Besra GS (2009) Structure of the diaminopimelate epimerase DapF from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr 65: 383387.
  • Vyas R, Kumar V, Panjikar S, Karthikeyan S, Kishan KV, Tewari R & Weiss MS (2008) Purification, crystallization and preliminary X-ray diffraction analysis of aspartate semialdehyde dehydrogenase (Rv3708c) from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 64: 167170.
  • Weyand S, Kefala G & Weiss MS (2006) Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of DapC (Rv0858c) from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 62: 794797.
  • Weyand S, Kefala G & Weiss MS (2007) The three-dimensional structure of N-succinyldiaminopimelate aminotransferase from Mycobacterium tuberculosis. J Mol Biol 367: 825838.
  • Wheeler PR & Blanchard JS (2005). General metabolism and biochemical pathways of tubercle bacilli. Tuberculosis and The Tubercle Bacillus (Cole ST, Eisenach KD, McMurray DN & Jacobs WR Jr, eds), pp. 309340. ASM Press, Washington, DC.
  • Wietzerbin J, Das BC, Petit JF, Lederer E, Leyh-Bouille M & Ghuysen JM (1974) Occurrence of D-alanyl-(D)-meso-diaminopimelic acid and meso-diaminopimelyl-meso-diaminopimelic acid interpeptide linkages in the peptidoglycan of mycobacteria. Biochemistry 13: 34713476.