Pathology of hepatitis C

Authors

  • Michael A. Gerber

    Corresponding author
    1. Department of Pathology and Lahoratory Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, Box SL79, New Orleans, Louisiana, 70772, USA
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*Corresponding author. Tel.: (504) 588 5210; Fax: (504) 587 7389

Abstract

Abstract: The basic morphological patterns of acute or chronic viral hepatitides are very similar, irrespective of the causative hepatitis viruses A, B, C, D or E. In addition, however, acute and chronic hepatitis C shows characteristic, although not pathognomonic histological changes. These consist of lymphoid aggregates in portal tracts, sometimes with germinal centers, damage of bile duct epithelium, and micro- or macrovesicular steatosis of hepatocytes. A combination of two of these three characteristic alterations is seen in over half of the patients with chronic hepatitis C and is helpful in the histological diagnosis of the disease.

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