Pathology of hepatitis C


  • Michael A. Gerber

    Corresponding author
    1. Department of Pathology and Lahoratory Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, Box SL79, New Orleans, Louisiana, 70772, USA
    Search for more papers by this author

*Corresponding author. Tel.: (504) 588 5210; Fax: (504) 587 7389


Abstract: The basic morphological patterns of acute or chronic viral hepatitides are very similar, irrespective of the causative hepatitis viruses A, B, C, D or E. In addition, however, acute and chronic hepatitis C shows characteristic, although not pathognomonic histological changes. These consist of lymphoid aggregates in portal tracts, sometimes with germinal centers, damage of bile duct epithelium, and micro- or macrovesicular steatosis of hepatocytes. A combination of two of these three characteristic alterations is seen in over half of the patients with chronic hepatitis C and is helpful in the histological diagnosis of the disease.