Virulence genes in the pathogenic yeast Candida albicans

Authors

  • Federico Navarro-García,

    1. Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, E-28040 Madrid, Spain
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  • Miguel Sánchez,

    1. Departamento de Microbiología y Genética, Edificio Departamental, Universidad de Salamanca/CSIC, Plaza de los Doctores de la Reina s/n, E-37007 Salamanca, Spain
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  • César Nombela,

    1. Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, E-28040 Madrid, Spain
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  • Jesús Pla

    Corresponding author
    1. Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, E-28040 Madrid, Spain
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*Corresponding author. Tel.: +34 (91) 3941617; Fax: +34 (91) 3941745, E-mail address: jesuspla@eucmax.sim.ucm.es

Abstract

In recent years, the incidence of fungal infections has been rising all over the world. Although the amount of research in the field of pathogenic fungi has also increased, there is still a need for the identification of reliable determinants of virulence. In this review, we focus on identified Candida albicans genes whose deletant strains have been tested in experimental virulence assays. We discuss the putative relationship of these genes to virulence and also outline the use of new different systems to examine the precise effect in virulence of different genes.

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