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The role of iron in Campylobacter gene regulation, metabolism and oxidative stress defense
Article first published online: 9 JAN 2006
DOI: 10.1111/j.1574-6976.2002.tb00609.x
1574-6976/asset/cover.gif?v=1&s=b95f34cc09a6786b349a46302cc75ed04179c14f "FEMS Microbiology Reviews")
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How to Cite
van Vliet, A. H.M., Ketley, J. M., Park, S. F. and Penn, C. W. (2002), The role of iron in Campylobacter gene regulation, metabolism and oxidative stress defense. FEMS Microbiology Reviews, 26: 173–186. doi: 10.1111/j.1574-6976.2002.tb00609.x
Publication History
- Issue published online: 9 JAN 2006
- Article first published online: 9 JAN 2006
- Received 23 November 2001, Revised 5 February 2002, Accepted 8 February 2002
- Abstract
- Article
- References
- Cited By
Keywords:
- Campylobacter;
- Iron transport;
- Iron storage;
- Oxidative stress defense;
- Ferric uptake regulator;
- Fur;
- PerR
Abstract
Enteric Campylobacter species cause gastrointestinal diseases in humans. Like almost all organisms, campylobacters have an absolute requirement for iron, but are faced with variable availability of iron in the environment and host tissues. Campylobacters have developed mechanisms to scavenge sufficient iron for metabolism and growth. However, iron also participates in the formation of reactive oxygen species, and this forces pathogens to maintain intracellular iron homeostasis and to cope with oxidative stresses. The presence of two separate, but possibly overlapping iron-responsive regulatory systems, which regulate iron acquisition and oxidative stress defense, and the presence of genes encoding multiple iron acquisition and detoxification systems in Campylobacter indicate the central role that iron plays in Campylobacter gene regulation and virulence.