Editor: Simon Cutting
The σ factors of Mycobacterium tuberculosis
Article first published online: 4 AUG 2006
FEMS Microbiology Reviews
Volume 30, Issue 6, pages 926–941, November 2006
How to Cite
Rodrigue, S., Provvedi, R., Jacques, P.-É., Gaudreau, L. and Manganelli, R. (2006), The σ factors of Mycobacterium tuberculosis. FEMS Microbiology Reviews, 30: 926–941. doi: 10.1111/j.1574-6976.2006.00040.x
- Issue published online: 17 AUG 2006
- Article first published online: 4 AUG 2006
- Received 6 April 2006; revised 13 June 2006; accepted 17 June 2006.First published online 4 August 2006.
- σ factor;
- posttranslational regulation;
- stress response;
Mycobacterium tuberculosis is a remarkable pathogen capable of adapting and surviving in various harsh conditions. Correct gene expression regulation is essential for the success of this process. The reversible association of different σ factors is a common mechanism for reprogramming bacterial RNA polymerase and modulating the transcription of numerous genes. Thirteen putative σ factors are encoded in the M. tuberculosis genome, several being important for virulence. Here, we analyse the latest information available on mycobacterial σ factors and discuss their roles in the physiology and virulence of M. tuberculosis.