Editor: Matthias Frosch
Conquering the Meningococcus
Article first published online: 4 JAN 2007
FEMS Microbiology Reviews
Volume 31, Issue 1, pages 3–14, January 2007
How to Cite
Stephens, D. S. (2007), Conquering the Meningococcus. FEMS Microbiology Reviews, 31: 3–14. doi: 10.1111/j.1574-6976.2006.00051.x
- Issue published online: 4 JAN 2007
- Article first published online: 4 JAN 2007
- Received 6 September 2006; revised 19 October 2006; accepted 22 October 2006.First published online January 2007.
- Neisseria meningitidis;
Since the first outbreaks of meningococcal meningitis were first described in Geneva in 1804 and in New England in 1806, and since the discovery of the causative agent by Weichselbaum in 1887 and the beginning of epidemics of meningococcal meningitis in the sub-Saharan Africa ∼100 years ago, Neisseria meningitidis has been recognized as the cause worldwide of epidemic meningitis and meningococcemia. The massive epidemic outbreaks in sub-Saharan Africa in the 1990's, the emergence since 1995 of serogroups Y, W-135 and X and the prolonged outbreak of serogroup B meningococcal disease in New Zealand over the last decade serve to remind us of the continued potential of the meningococcus to cause global morbidity and mortality. This report reviews new discoveries impacting prevention and future prospects for conquering the meningococcus as a human pathogen.