Editor: Arie van der Ende
Peptidoglycan structure and architecture
Article first published online: 8 JAN 2008
© 2008 Federation of European Microbiological Societies
FEMS Microbiology Reviews
Volume 32, Issue 2, pages 149–167, March 2008
How to Cite
Vollmer, W., Blanot, D. and De Pedro, M. A. (2008), Peptidoglycan structure and architecture. FEMS Microbiology Reviews, 32: 149–167. doi: 10.1111/j.1574-6976.2007.00094.x
- Issue published online: 11 FEB 2008
- Article first published online: 8 JAN 2008
- Received 12 July 2007; revised 21 October 2007; accepted 22 October 2007.First published online 8 January 2008.
- bacterial cell wall
The peptidoglycan (murein) sacculus is a unique and essential structural element in the cell wall of most bacteria. Made of glycan strands cross-linked by short peptides, the sacculus forms a closed, bag-shaped structure surrounding the cytoplasmic membrane. There is a high diversity in the composition and sequence of the peptides in the peptidoglycan from different species. Furthermore, in several species examined, the fine structure of the peptidoglycan significantly varies with the growth conditions. Limited number of biophysical data on the thickness, elasticity and porosity of peptidoglycan are available. The different models for the architecture of peptidoglycan are discussed with respect to structural and physical parameters.