Editor: Jacques Coyette
Penicillin-binding proteins and β-lactam resistance
Version of Record online: 31 JAN 2008
© 2008 Federation of European Microbiological Societies
FEMS Microbiology Reviews
Volume 32, Issue 2, pages 361–385, March 2008
How to Cite
Zapun, A., Contreras-Martel, C. and Vernet, T. (2008), Penicillin-binding proteins and β-lactam resistance. FEMS Microbiology Reviews, 32: 361–385. doi: 10.1111/j.1574-6976.2007.00095.x
- Issue online: 11 FEB 2008
- Version of Record online: 31 JAN 2008
- Received 6 June 2007; revised 13 September 2007; accepted 23 October 2007.First published online February 2008.
- Staphylococcus aureus;
- Streptococcus pneumoniae;
A number of ways and means have evolved to provide resistance to eubacteria challenged by β-lactams. This review is focused on pathogens that resist by expressing low-affinity targets for these antibiotics, the penicillin-binding proteins (PBPs). Even within this narrow focus, a great variety of strategies have been uncovered such as the acquisition of an additional low-affinity PBP, the overexpression of an endogenous low-affinity PBP, the alteration of endogenous PBPs by point mutations or homologous recombination or a combination of the above.