Editor: Fergus Priest
From soil to gut: Bacillus cereus and its food poisoning toxins
Article first published online: 16 APR 2008
© 2008 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved
FEMS Microbiology Reviews
Volume 32, Issue 4, pages 579–606, July 2008
How to Cite
Stenfors Arnesen, L. P., Fagerlund, A. and Granum, P. E. (2008), From soil to gut: Bacillus cereus and its food poisoning toxins. FEMS Microbiology Reviews, 32: 579–606. doi: 10.1111/j.1574-6976.2008.00112.x
- Issue published online: 24 APR 2008
- Article first published online: 16 APR 2008
- Received 20 December 2007; revised 13 February 2008; accepted 20 February 2008.First published online 16 April 2008.
- Bacillus cereus;
- foodborne disease;
- tripartite toxin
Bacillus cereus is widespread in nature and frequently isolated from soil and growing plants, but it is also well adapted for growth in the intestinal tract of insects and mammals. From these habitats it is easily spread to foods, where it may cause an emetic or a diarrhoeal type of food-associated illness that is becoming increasingly important in the industrialized world. The emetic disease is a food intoxication caused by cereulide, a small ring-formed dodecadepsipeptide. Similar to the virulence determinants that distinguish Bacillus thuringiensis and Bacillus anthracis from B. cereus, the genetic determinants of cereulide are plasmid-borne. The diarrhoeal syndrome of B. cereus is an infection caused by vegetative cells, ingested as viable cells or spores, thought to produce protein enterotoxins in the small intestine. Three pore-forming cytotoxins have been associated with diarrhoeal disease: haemolysin BL (Hbl), nonhaemolytic enterotoxin (Nhe) and cytotoxin K. Hbl and Nhe are homologous three-component toxins, which appear to be related to the monooligomeric toxin cytolysin A found in Escherichia coli. This review will focus on the toxins associated with foodborne diseases frequently caused by B. cereus. The disease characteristics are described, and recent findings regarding the associated toxins are discussed, as well as the present knowledge on virulence regulation.