Editor: Neil Fairweather
Molecular and infection biology of the horse pathogen Rhodococcus equi
Article first published online: 23 APR 2009
© 2009 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved
FEMS Microbiology Reviews
Volume 33, Issue 5, pages 870–891, September 2009
How to Cite
Von Bargen, K. and Haas, A. (2009), Molecular and infection biology of the horse pathogen Rhodococcus equi. FEMS Microbiology Reviews, 33: 870–891. doi: 10.1111/j.1574-6976.2009.00181.x
- Issue published online: 30 JUL 2009
- Article first published online: 23 APR 2009
- Received 5 December 2008; revised 12 March 2009; accepted 21 March 2009.Final version published online 23 April 2009.
- Rhodococcus equi;
- Mycobacterium tuberculosis
The soil actinomycete Rhodococcus equi is a pulmonary pathogen of young horses and AIDS patients. As a facultative intracellular bacterium, R. equi survives and multiplies in macrophages and establishes its specific niche inside the host cell. Recent research into chromosomal virulence factors and into the role of virulence plasmids in infection and host tropism has presented novel aspects of R. equi infection biology and pathogenicity. This review will focus on new findings in R. equi biology, the trafficking of R. equi-containing vacuoles inside host cells, factors involved in virulence and host resistance and on host–pathogen interaction on organismal and cellular levels.