Editor: Juan L. Ramos
AraC protein, regulation of the l-arabinose operon in Escherichia coli, and the light switch mechanism of AraC action
Article first published online: 8 APR 2010
© 2010 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved
FEMS Microbiology Reviews
Special Issue: Global control
Volume 34, Issue 5, pages 779–796, September 2010
How to Cite
Schleif, R. (2010), AraC protein, regulation of the l-arabinose operon in Escherichia coli, and the light switch mechanism of AraC action. FEMS Microbiology Reviews, 34: 779–796. doi: 10.1111/j.1574-6976.2010.00226.x
- Issue published online: 2 AUG 2010
- Article first published online: 8 APR 2010
- Received 9 February 2010; revised 30 March 2010; accepted 5 April 2010.Final version published online 18 May 2010.
- transcription initiation;
- RNA polymerase;
This review covers the physiological aspects of regulation of the arabinose operon in Escherichia coli and the physical and regulatory properties of the operon's controlling gene, araC. It also describes the light switch mechanism as an explanation for many of the protein's properties. Although many thousands of homologs of AraC exist and regulate many diverse operons in response to many different inducers or physiological states, homologs that regulate arabinose-catabolizing genes in response to arabinose were identified. The sequence similarities among them are discussed in light of the known structure of the dimerization and DNA-binding domains of AraC.