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An inventory of the bacterial macromolecular components and their spatial organization
Article first published online: 22 OCT 2010
DOI: 10.1111/j.1574-6976.2010.00254.x
© 2010 Fourmentin-Guilbert Foundation. FEMS Microbiology Reviews © 2010 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd
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How to Cite
Vendeville, A., Larivière, D. and Fourmentin, E. (2011), An inventory of the bacterial macromolecular components and their spatial organization. FEMS Microbiology Reviews, 35: 395–414. doi: 10.1111/j.1574-6976.2010.00254.x
Publication History
- Issue published online: 1 FEB 2011
- Article first published online: 22 OCT 2010
- Accepted manuscript online: 27 SEP 2010 10:36AM EST
- Received 15 April 2010; revised 8 September 2010; accepted 9 September 2010., Final version published online 22 October 2010.
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Keywords:
- bacterial metabolism;
- protein abundance;
- macromolecular crowding;
- space management
Abstract
Formerly regarded as small ‘bags’ of nucleic acids with randomly diffusing enzymes, bacteria are organized by a sophisticated and tightly regulated molecular machinery. Here, we review qualitative and quantitative data on the intracellular organization of bacteria and provide a detailed inventory of macromolecular structures such as the divisome, the degradosome and the bacterial ‘nucleolus’. We discuss how these metabolically active structures manage the spatial organization of the cell and how macromolecular crowding influences them. We present for the first time a visualization program, lifeexplorer, that can be used to study the interplay between metabolism and spatial organization of a prokaryotic cell.