Present address: Christopher L. Baker, The Jackson Laboratory, 600 Main Street, Box 75, Bar Harbor, ME 04609, USA.
The circadian clock of Neurospora crassa
Article first published online: 1 AUG 2011
© 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved
FEMS Microbiology Reviews
Special Issue: Microbial Development
Volume 36, Issue 1, pages 95–110, January 2012
How to Cite
Baker, C. L., Loros, J. J. and Dunlap, J. C. (2012), The circadian clock of Neurospora crassa. FEMS Microbiology Reviews, 36: 95–110. doi: 10.1111/j.1574-6976.2011.00288.x
Editor: Gerhard Braus
- Issue published online: 12 DEC 2011
- Article first published online: 1 AUG 2011
- Accepted manuscript online: 27 JUN 2011 12:15PM EST
- Received 17 February 2011; accepted 8 June 2011.
- circadian rhythms;
- negative feedback;
- post-translational modification;
- protein phosphorylation;
- white collar
Circadian clocks organize our inner physiology with respect to the external world, providing life with the ability to anticipate and thereby better prepare for major fluctuations in its environment. Circadian systems are widely represented in nearly all major branches of life, except archaebacteria, and within the eukaryotes, the filamentous fungus Neurospora crassa has served for nearly half a century as a durable model organism for uncovering the basic circadian physiology and molecular biology. Studies using Neurospora have clarified our fundamental understanding of the clock as nested positive and negative feedback loops regulated through transcriptional and post-transcriptional processes. These feedback loops are centered on a limited number of proteins that form molecular complexes, and their regulation provides a physical explanation for nearly all clock properties. This review will introduce the basics of circadian rhythms, the model filamentous fungus N. crassa, and provide an overview of the molecular components and regulation of the circadian clock.