Recent progress in Bacillus subtilis sporulation


Correspondence: Jonathan Dworkin, 701 W. 168th St., Room 1218, New York, NY 10032, USA. Tel.: 212 342 3731; fax: 212 305 1468; e-mail:


The Gram-positive bacterium Bacillus subtilis can initiate the process of sporulation under conditions of nutrient limitation. Here, we review some of the last 5 years of work in this area, with a particular focus on the decision to initiate sporulation, DNA translocation, cell–cell communication, protein localization and spore morphogenesis. The progress we describe has implications not only just for the study of sporulation but also for other biological systems where homologs of sporulation-specific proteins are involved in vegetative growth.