• 1
    Bishop J. M., The molecular genetics of cancer, Science, 235: 305311, 1987.
  • 2
    Hanahan D., Weinberg, R. A., The hallmarks of cancer, Cell, 100: 5770, 2000.
  • 3
    Rabbitts T. H., Chromosomal translocations in human cancer, Nature, 372: 143149, 1994.
  • 4
    Mitelman F., Mertens F., Johansson B., A breakpoint map of recurrent chromosomal rearrangements in human neoplasis, Nat. Genet., 15: 417474, 1997.
  • 5
    Grisham J. W., Interspecies comparison of liver carcinogenesis implications for cancer risk assessment, Carcinogenesis, 18: 5981, 1996.
  • 6
    Hueber A. O., Evan G. I., Traps to catch unwary oncogenes, Trends Genet., 14: 364367, 1998.
  • 7
    O'Dwyer M. E., Mauro M. J., and Druker B. J., Recent advancement in the treatment of chronic myelogenous leukemia, Annu. Rev. Med., 53: 369381, 2002.
  • 8
    Nowell P., Dalla-Favera R., Finan J., Erikson J., Croce C., Chromosome translocations, immunoglobulin genes, and neoplasia. In RowleyJ. D., UltmannJ. E. (eds). Chromosomes and cancer: from molecules to man. New York : Academic Press; 1983, pp. 165181.
  • 9
    Dalla-Favera R., Bregni M., Erikson J., Patterson D., Gallo R. C., Croce C. M., Human c-myc oncogene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells, Proc. Natl. Acad. Sci. U. S. A., 79: 78247827, 1982.
  • 10
    Pelicci P. G., Knowles D. M. D., Magrath I., Dalla-Favera R., Chromosomal breakpoints and structural alterations of the c-myc locus differ in endemic and sporadic forms of Burkitt lymphoma, Proc. Natl. Acad. Sci. U. S. A., 83: 29842988, 1986.
  • 11
    Croce C. M., Nowell P. C., Molecular basis of B-cell neoplasia, Blood, 55: 17, 1985.
  • 12
    Croce C. M., Role of chromosome translocation in human neoplasia, Cell, 49: 155156, 1987.
  • 13
    Haluska F. G., Tsujimoto Y., Russo G., Isobe M., Croce C. M., Molecular genetics of lymphoid tumorigenesis, Prog. Nucleic Acid Res. Mol. Biol., 36: 269280, 1989.
  • 14
    Showe L. C., Ballantine M., Nishikura K., Erikson J., Kaji H., Croce C. M., Cloning and sequencing of a c-myc oncogene in a Burkitt's lymphoma cell line that is translocated to a germ line alpha switch region, Mol. Cell. Biol., 5: 501509, 1985.
  • 15
    Zimonjic D. B., Keck-Waggoner C. L., Popescu N. C., Novel genomic imbalances and chromosome translocations involving c-myc gene in Burkitt's lymphoma, Leukemia, 15: 15821588, 2001.
  • 16
    Gurtsevitch V. E., O'Conor G. T., Lenoir G. M., Burkitt's lymphoma cell lines reveal different degrees of tumorigenicity in nude mice, Int. J. Cancer., 41: 8795, 1988.
  • 17
    Forozan F., Mahlamaki E. H., Monni O., Chen Y., Veldman R., Jiang Y., Gooden G. C., Ethier S. P., Kallioniemi A., Kallioniemi O. P., Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data, Cancer Res., 60: 45194525, 2000.
  • 18
    Tirkkonen M. T. M., Karhu R., Kallioniemi A., Isola J., Kallioniemi O. P., Molecular cytogenetics of primary breast cancer by CGH, Genes Chromosomes Cancer, 21: 177184, 1998.
  • 19
    Jain A. N., Chin K., Borresen-Dale A-L, Erikstein B. K., Lonning P. E., Kaaresen R., Gray J. W., Quantitative analysis of chromosomal CGH in human breast tumors associates copy number abnormalities with p53 status and patient survival, Proc. Natl. Acad. Sci. U. S. A., 98: 79527957, 2001.
  • 20
    Alitalo K., Schwab M., Oncogene amplification in tumor cells. Adv. Cancer Res., 47: 235281, 1986.
  • 21
    Schimke R. T., Gene amplification in cultured cells. J. Biol. Chem., 63: 59895992, 1988.
  • 22
    Pardue M. L., Dynamic instability of chromosomes and genomes, Cell, 66: 427431, 1991.
  • 23
    Kraus M.H., Popescu N.C., Amsbaugh S.C., King C.R., Overexpression of the Egf receptor-related proto-oncogene Erbb-2 in human mammary tumor cell lines by different molecular mechanisms, EMBO J., 6: 605610, 1987.
  • 24
    Slamon D.J., Clark G.M., Wong S.G., Levin W.J., Ullrich A., McGuire W.L., Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene, Science, 235: 177182, 1987.
  • 25
    Pegram M.D., Lipton A., Hayes D.F., Weber B. L., Baselga J.M., Tripathy D., Baly D., Baughman S.A., Twaddell T., Glaspy J.A., Slamon D.J., Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185 HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment, J. Clin. Oncol., 16: 26592671, 1998.
  • 26
    Zimonjic D.B., Keck-Waggoner C.L., Yuan B.Z., Kraus M.H., Popescu N.C., Profile of genetic alterations and tumoigenicity of human breast cancer cells, Int. J. Oncol., 16: 221230, 2000.
  • 27
    Hahn W.C., Counter C.M., Lundberg A.S., Beijersbergen R.L., Brooks M.W., Weinberg R. A., Creation of human tumor cells with defined genetic elements, Nature, 400: 464468, 1999.
  • 28
    Zimonjic D.B., Brooks M.W., Popescu N.C., Weinberg R.A., Hahn W.C., Derivation of human tumor cells in vitro without widespread genomic instability, Cancer Res., 61: 88388844, 2001.
  • 29
    Elenbaas B., Spirio L., Koerner F., Fleming M. D., Zimonjic D.B., Donaher J. L., Popescu N. C., Hahn, W. C., Weinberg R.A., Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells, Genes Dev., 15: 5065, 2001.
  • 30
    Lundin C., Mertens F., Cytogenetics of benign breast lesions, Breast Cancer Res. Treat., 51: 115, 1998.
  • 31
    Varmus H., Retroviruses, Science, 240: 14271435, 1988.
  • 32
    Peters G., Oncogenes at viral integration sites, Cell Growth Diff., 1: 503510, 1990.
  • 33
    Popescu N.C., Chromosome fragility and instability in human cancer, Crit. Rev. Oncog., 5: 121140, 1994.
  • 34
    Weinberg R.A., Integrated genomes of animal viruses, Ann. Rev. Biochem., 49: 197226, 1980.
  • 35
    Croce C.M., Integration of oncogenic viruses in mammalian cells, Int. Rev. Cytol., 71: 117, 1981.
  • 36
    Popescu N.C., DiPaolo J.A., Amsbaugh S.C., Integration sites of human papilloma-virus 18 DNA sequences on HeLa cell chromosomes, Cytogenet. Cell Genet., 44: 5862, 1987.
  • 37
    Popescu N.C., Zimonjic D.B, DiPaolo J.A., Viral integration, fragile sites and protooncogenes in human neoplasia, Hum. Genet., 84: 383386, 1989.
  • 38
    Zimonjic D.B., Druck T., Ohta M., Kastury K., Croce C.M., Popescu N.C., Huebner K., Positions of chromosome 3p14. 2 fragile sites (FRA3B) within the FHIT gene, Cancer Res., 57: 11661170, 1997.
  • 39
    Lazo P., DiPaolo J.A., Popescu N.C., Amplification of the integrated viral transforming genes of human papillomavirus 18 and 5′ flanking cellular sequence located near the myc proto-oncogene in HeLa cells, Cancer Res., 49: 43054310, 1989.
  • 40
    Wilke C.M., Hall B.K., Hoge A., Paradee W., Smith D.I., Glover, T.W., FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites, Hum. Mol. Genet., 5: 187195, 1996.
  • 41
    Thorland E.C., Myers S.L., Persing D.H., Sarkar G., McGovern R.M., Gostout, B.S., Smith, D.I., Human papillomavirus type 16 integrations in cervical tumors frequently occur in common fragile sites, Cancer Res., 60: 59165921, 2000.
  • 42
    Popescu N.C., DiPaolo J.A., Cytogenetics of cervical neoplasia, Cancer Genet. Cytogenet., 60: 214215, 1992.
  • 43
    Riou G., Le M.C., Favre M., Jeannel D., Bowrhis J., Orth G., Human papillomavirus-negative status and c-myc gene overexpression: independent prognostic indicators of distant metastasis for early-stage invasive cervical cancer, J. Natl. Canc. Inst., 84: 15251526, 1992.
  • 44
    Kotin R.M., Menninger J.C., Ward D.C., Berns K.I., Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter, Genomics, 10: 831834, 1991.
  • 45
    Samulski R.J., Zhu X., Xiao X., Brook J.D., Housman D.E., Epstein N., Hunter L.A., Targeted integration of adeno-associated virus (AAV) into human chromosome 19, EMBO J., 10: 39413950, 1991.
  • 46
    Rivadeneira E.D., Popescu N.C., Zimonjic D.B., Cheng G.S., Nelson P.J., Ross M.D., DiPaolo J. A., Klotman M.E., Sites of recombinant adeno-associated virus integration, Int. J. Oncol., 12: 805810, 1998.
  • 47
    Moroy T., Marchio A., Etiemble J., Trepo C., Tiollais P., Buendia M.A., Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks, Nature, 324: 276279, 1986.
  • 48
    Mizuno Y., Murukami S., Matsushita F., Unoura M., Kobayasi K., Migita S., Hatori N., Ohno S., Chromosomal assignment of woodchuck hepatitis virus (WHV) DNA integration sites in a woodchuck hepatocellular carcinoma-derived cell line (WH257GE10), Int. J. Cancer, 43: 652657, 1989.
  • 49
    Zimonjic D.B., Keck C.L., Thorgeirsson S.S., Popescu N.C., Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization. Hepatology, 29: 12081214, 1999.
  • 50
    Murakami H., Sanderson N., Nagy P., Marino P., Merlino G.T., Thorgeirsson S. S., Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and TGF-α in hepatic oncogenesis, Cancer Res., 53: 17191723, 1993.
  • 51
    Santoni-Rugiu E, Nagy P., Jensen M.R., Factor V. M., Thorgeirsson S.S., Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor, Am. J. Pathol., 149: 407428, 1996.
  • 52
    Santoni-Rugiu E., Jensen M.R., Thorgeirsson S. S., Disruption of the pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha, Cancer Res., 58: 123134, 1998.
  • 53
    Sargent L.M., Zhou X., Keck C.L., Sanderson N. D., Zimonjic D.B., Popescu N.C., Thorgeirsson, S.S., Nonrandom cytogenetic alterations in hepatocellular carcinoma from transgenic mice overexpressing c-myc and transforming growth factor alpha in the liver, Am. J. Path., 154: 10471055, 1999.
  • 54
    Keck C.L., Zimonjic D.B., Yuan, B.Z., Thorgeirsson S.S., Popescu N.C., Nonrandom breakpoints of unbalanced chromosome translocations in human hepatocellular carcinoma cell lines, Cancer Genet. Cytogenet., 111: 3744, 1999.
  • 55
    Popescu N. C., Zimonjic D.B., Chromosome and gene alterations in breast cancer as markers for diagnosis and prognosis as well as targets for therapy, Am. J. Med. Genet. , 2002 (In Press).