• 1
    Kang J., Lemaire H.G., Unterbeck A., Salbaum J.M., Master C.L., Grzeschik K.H., Multhaup G., Beyreuther K., Muller-Hill B., The precursor of Alzheimer's disease precursor protein resembles a cell-surface receptor, Nature, 325: 733736, 1987.
  • 2
    Dodart J., Mathis C., Ungerer A., The beta-amyloid precursor protein and its derivatives: from biology to learning and memory processes, Rev. Neurosci., 11: 7593, 2000.
  • 3
    Morimoto T., Ohsawa I., Takamura C., Ishiguro M., Kohsaka S., Involvement of amyloid precursor protein in functional synapse formation in cultured hippocampal neurons, J. Neurosci. Res., 51: 185195, 1998.
  • 4
    Perez R., Zhenh H., Van der Ploeg L., Koo E., The β-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity, J. Neurosci., 15: 94079414, 1997.
  • 5
    Vassar R., Bennett B.D., Babu-Khan S., Kahn S., Mendiaz E.A., Denis P., Teplow D.B., Ross S., Amarante P., Loeloff R., Luo Y., Fisher S., Fuller J., Edenson S., Lile J., Jarosinski M.A., Biere A.L., Curran E., Burgess T., Louis J.-C., Colins F., Treanor J., Rogers G., Citron M., β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE, Science, 286: 735741, 1999.
  • 6
    Citron M., Teplow T.B., Selkoe D.J., Generation of amyloid beta protein from its precursor is sequence specific, Neuron, 14: 661670, 1995.
  • 7
    Hardy J., Amyloid, the presenilins and Alzheimer's disease, Trends Neurosci., 20: 154159, 1997.
  • 8
    McKhann G., Drachmann D., Folstein M., Katzman R., Price D., Stadlan E.M., Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services task force on Alzheimer's disease, Neurology, 34: 939944, 1989.
  • 9
    Mirra S., Heyman A., McKeel D., Sumi S., Crain B., Brownlee L., Vogel F., Hughes J., Van Belle G., Berg L., The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology, 41: 479486, 1991.
  • 10
    Sennvik K., Fastbom J., Blomberg M., Wahlund L.-O., Winblad B., Benedikz E., Levels of α- and β-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients, Neuroscience Letters, 278: 169172, 2000.
  • 11
    Anderton B., Callahan L., Coleman P., Davies P., Flood D., Jicha G., Ohms T., Weaver C., Dendritic changes in Alzheimer's disease and factors that may underlie those changes, Prog. Neurobiol., 55: 595609, 1998.
  • 12
    Arendt T., Alzheimer's disease as a disorder of mechanisms underlying structural brain selforganisation, Neuroscience, 102: 723765, 2001.
  • 13
    Rossner S., Apelt J., Schliebs R., Perez-Polo J., Bigl V., Neuronal and glial betasecretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology, J. Neurosci. Res., 64: 437446, 2001.
  • 14
    Kasa P., Papp H., Kovacs I., Forgon M., Penke B., Yamaguchi, H., Human amyloid-β1-42 applied in vivo inhibits the fast axonal transport of proteins in the sciatic nerve of rat, Neurosci. Lett., 278: 117119, 2000.
  • 15
    Maldonado T., Jones R., Norris D., Distribution of β-amyloid and amyloid precursor protein in the brain of spawning(senescent) salmon: a natural, brain-aging model, Brain Res., 858: 237251, 2000.
  • 16
    Campbell E., Pearson R., Parkinson D., Methods to uncover an antibody epitope in the KPI domain of Alzheimer's amyloid precursor protein for immunohistochemistry in human brain, J. Neurosci. Meth., 93: 133138, 1999.
  • 17
    Tagliavini F., Giaccone G., Verga L., Ghiso J., Frangione B., Bugiani O., Alzheimer's patients: pre-amyloid deposits are immunoreactive with antibodies to extracellular domains of the amyloid precursor protein, Neurosci. Lett., 128: 117120, 1991.
  • 18
    Takahashi H., Kurashima C., Utsuyama M., Hirokawa K., Immunohistological study of senile brains by using a monoclonal antibody recognizing β amyloid precursor protein: significance of granular deposits in relation with senile plaques, Acta Neuropathologica, 80: 260265, 1990.
  • 19
    Joachim C., Games D., Morris J., Ward P., Frenkel D., Selkoe, D., Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques, Am. J. Pathol., 138: 373384, 1991.
  • 20
    Rozemuller A., Roos R., Bots G., Kamphorst W., Eikelenboom P., Van Nostrand W., Distribution of β/A4 protein and amyloid precursor protein in hereditary cerebral hemorrhage with amyloidosis-dutch type and Alzheimer's disease, Am. J. Pathol., 142: 14491457, 1993.
  • 21
    Caporaso G., Takei K., Gandy S., Matteoli M., Mundigl O., Greengard P., De Camilli P., Morphological and biochemical analysis of the intracellular trafficking of the Alzheimer b/A4 amyloid precursor protein, J. Neurosci., 14: 312231318, 1994.
  • 22
    Sheetz M., Pfister K., Bulinsku J., Cotman C., Mechanisms of trafficking in axons and dendrites: implications for development and neurodegeneration, Prog. Neurobiol., 55: 577594, 1998.
  • 23
    Simons M., Ikonen E., Tienari P., Cid-Arregui A., Mönning U., Beyreuther K., Dotti C., Intracellular routing of human amyloid protein precursor: axonal delivery followed by transport to the dendrites, J. Neurosci. Res., 41: 121128, 1995.
  • 24
    Stone J., Singleton R., Povlishock J., Antibodies to the C-terminus of the b-amyloid precursor protein (APP): a site-specific marker for the detection of traumatic axonal injury, Brain Res., 871: 288302, 2000.
  • 25
    Tienari P., De Strooper B., Ikonen E., Simons M., Weidemann A., Czech C., Hartmann T., Ida N., Multhaup G., Masters C., Van Leuven F., Beyreuther K., Dotti C., The β-amyloid domain is essential for axonal sorting of amyloid precursor protein, EMBO J., 15: 52181529, 1996.
  • 26
    Yamazaki T., Selkoe D., Koo E., Trafficking of cell surface β- amyloid precursor protein: Retrograde and transcytotic transport in cultured neurons, J. Cell Biol., 129: 431, 1995.
  • 27
    Santiago-Garcia J., Mas-Oliva J., Innerarity T., Pitas R., Secreted forms of the amyloid-beta precursor protein are ligands for the class A scavenger receptor, J. Biol. Chem., 276: 3065561, 2001.
  • 28
    Amaratunga A., Fine R., Generation of amyloidogenic C-terminal fragments during rapid axonal transport in vivo of β-amyloid precursor protein in the optic nerve, J. Biol. Chem., 270: 1726817272, 1995.
  • 29
    Lyckman A., Confaloni A., Thinakaran G., Sisodia S., Moya K., Post-translational processing and turnover kinetics of presynaptically targeted amyloid precursor superfamily proteins in the central nervous system, J. Biol. Chem., 273: 1110011106, 1998.
  • 30
    Storey E., Beyreuther K., Masters C., Alzheimer's disease amyloid precursor protein on the surface of cortical neurons in primary culture co-localizes with adhesion patch components, Brain Res., 735: 217231, 1996.
  • 31
    Kamal A., Stokin G., Yang Z., Xia C.-H., Goldstein L., Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-1, Neuron, 26: 449459, 2000.
  • 32
    Gunawardena S., Goldstein L., Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila, Neuron, 32: 389401, 2001.
  • 33
    Bogdanovic N., Davidsson P., Volkmann I., Winblad B., Blennow K., Growth-associated protein GAP-43 in the frontal cortex and in the hippocampus in Alzheimer's disease: an immunohistochemical and quantitative study, J. Neural Transm., 107: 463478, 2000.