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  • 1
    Nicholson K.M., Anderson N.G., The Akt/PKB signalling pathway in human malignancy, Cell signal, 14: 381395, 2002.
  • 2
    Hajduch E, Litherland G.J., Hundal H.S., Protein kinase B (Akt/PKB)-a key regulator of glucose transport?, FEBS Lett., 492: 199203, 2001.
  • 3
    Coffer P.J., Woodgett J.R., Molecular cloning and characterization of a novel putative protein-serine kinase related to the cAMP dependent and protein kinase C families, Eur. J. Biochem., 201: 475481, 1991.
  • 4
    Jones P.F., Jakubowicz T., Pitossi F.J., Maurer F., Hemmings B.A., Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily, Proc. Natl. Acad. Sci. USA., 88: 41714175, 1991.
  • 5
    Bellacosa A., Testa J.R., Staal S.P., Tsichlis P.N., A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region, Science, 254: 274277, 1991.
  • 6
    Jones P.F., Jakubowicz T., Hemmings B.A., Molecular cloning of a second form of rac protein kinase, Cell Regul., 2: 10011009, 1991.
  • 7
    Cheng J.Q., Godwin A.K., Bellacosa A., Taguchi T., Franke T.F., Hamilton T.C., Tsichlis P.N., Testa J.R., AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas, Proc. Natl. Acad. Sci. USA., 89: 92679271, 1992.
  • 8
    Brodbeck D., Cron P., Hemmings B.A., A human protein kinase B with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain, J. Biol. Chem., 274: 91339136, 1999.
  • 9
    Brazil D.P., Hemmings B.A., Ten years of protein kinase B signalling: a hard Akt to follow, Trends Biochem. Sci., 26: 657664, 2001.
  • 10
    Tyers M., Rachubinski R.A., Stewart M.I., Varrichio A.M., Shorr R.G., Haslam R.J., Harley C.B., Molecular cloning and expression of the major protein kinase C substrate of platelets, Nature, 333: 470473, 1998.
  • 11
    Lietzke S.E., Bose S., Cronin T., Klarlund J., Chawla A., Czech M.P., Lambright D.G., Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains, Mol Cell, 6: 385394, 2000.
  • 12
    Ferguson K.M., Kavran J.M., Sankaran V.G., Fournier E., Isakoff S.J., Skolnik E.Y., Lemmon M.A., Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains, Mol. Cell, 6: 373384, 2000.
  • 13
    James S.R., Downes C.P., Gigg R., Grove S.J., Holmes A.B., Alessi D.R., Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation, Biochem. J., 315: 709713, 1996.
  • 14
    Frech M., Andjelkovic M., Ingley E., Reddy K.K., Falck J.R., Hemmings B.A., High affinity binding of inositol phosphates and phosphoinositides to the Pleckstrin homology domain of RAC protein kinase B and their influence on kinase activity, J. Biol. Chem., 272: 84748481, 1997.
  • 15
    Thomas C.C., Deak M., Alessi D.R., Van Aalten D.M., High-resolution structure of the pleckstrin homology domain of Akt/PKB bound to phosphatidylinositol (3,4,5)- trisphosphate, Curr. Biol., 12: 12561262, 2002.
  • 16
    Peterson R.T., Schreiber S.L., Kinase phosphorylation: keeping it all in the family, Curr. Biol., 9: R521524, 1999.
  • 17
    Alessi D.R., Andjelkovic M., Caudwell B., Cron P., Morrice N., Cohen P., Hemmings B.A., Mechanism of activation of protein kinase B by insulin and IGF-1, EMBO. J., 15: 65416551, 1996.
  • 18
    Andjelkovic M., Alessi D.R., Meier R., Fernandez A., Lamb N.J., Frech M., Cron P., Cohen P., Lucocq J.M., Hemmings B.A., Role of translocation in the activation and function of protein kinase B, J. Biol. Chem., 272: 3151531524, 1997.
  • 19
    Brodbeck D., Hill M.M., Hemmings B.A., Two splice variants of protein kinase B g have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site serine 472 in the carboxyl-terminal hydrophobic domain, J. Biol. Chem., 276: 2955029558, 2001.
  • 20
    Konishi H., Kuroda S., Tanaka M., Matsuzaki H., Ono Y., Kameyama K., Haga T., Kikkawa U., Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins, Biochem. Biophys. Res. Commun., 216: 526534, 1995.
  • 21
    Wymann M.P., Zvelebil M., Laffargue M., Phosphoinositide 3-kinase signaling-which way to target?, Trends Pharmacol. Sci., 24: 366376, 2003.
  • 22
    Simpson L., Parsons R., PTEN: life as a tumor suppressor, Exp. Cell. Res, 264: 2941, 2001.
  • 23
    Lemmon M.A., Ferguson K.M., Signal-dependent membrane targeting by pleckstrin homology (PH) domains, Biochem. J., 350: 118, 2000.
  • 24
    Andjelkovic M., Alessi D.R., Meier R., Fernandez A., Lamb N.J., Frech M., Cron P., Cohen P., Lucocq J.M., Hemmings B.A., Role of translocation in the activation and function of protein kinase B, J. Biol. Chem., 272: 3151531524, 1997.
  • 25
    Stephens L., Anderson K., Stokoe D., Erdjument-Bromage H., Painter G.F., Holmes A.B., Gaffney P.R., Reese C.B., McCormick F., Tempst P., Coadwell J., Hawkins P.T., Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B, Science, 279: 710714, 1998.
  • 26
    Toker A., Newton A.C., Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site, J. Biol. Chem., 275: 82718274, 2000.
  • 27
    Persad S., Attwell S, Gray V., Mawji N., Deng J.T., Leung D., Yan J., Sanghera J., Walsh M.P., Dedhar S., Regulation of Akt/PKB-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343, J. Biol. Chem., 276: 2746227469, 2001.
  • 28
    Conus N.M., Hannan K.M., Cristiano B.E., Hemmings B.A., Pearson R.B., Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase, J. Biol. Chem., 277: 3802138028, 2002.
  • 29
    Jiang T., Qiu Y., Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation, J. Biol. Chem., 278: 1578915793, 2003.
  • 30
    Mora A., Komander D., Van Aalten D.M., Alessi D.R., PDK1, the master regulator of AGC kinase signal transduction, Semin Cell Dev. Biol., 15: 161170, 2004.
  • 31
    Biondi R.M., Cheung P.C., Casamayor A., Deak M., Currie R.A., Alessi D.R., Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA, EMBO. J., 19: 979988, 2000.
  • 32
    Biondi R.M., Kieloch A., Currie R.A., Deak M., Alessi D.R., The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB, EMBO. J., 20: 43804390, 2001.
  • 33
    Collins B.J., Deak M., Arthur J.S., Armit L.J., Alessi D.R., In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation, EMBO. J., 22: 42024211, 2003.
  • 34
    Anderson K.E., Coadwell J., Stephens L.R., Hawkins P.T., Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B, Curr. Biol., 8: 684691, 1998.
  • 35
    Balendran A., Casamayor A., Deak M., Paterson A., Gaffney P., Currie R., Downes C.P., Alessi D.R., PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2, Curr. Biol., 9: 393404, 1999.
  • 36
    Williams M.R., Arthur J.S., Balendran A., van der Kaay J., Poli V., Cohen P., Alessi D.R., The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells, Curr. Biol., 10: 439448, 2000.
  • 37
    Hill M.M., Andjelkovic M., Brazil D.P., Ferrari S., Fabbro D., Hemmings B.A., Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase, J. Biol. Chem., 276: 2564325646, 2001.
  • 38
    Toker A., Newton A.C., Akt/Protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site, J. Biol. Chem., 275: 82718274, 2000.
  • 39
    Laine J., Kunstle G., Obata T., Sha M., Noguchi M., The protooncogene TCL1 is an Akt kinase coactivator, Mol. Cell, 6: 395407, 2000.
  • 40
    Hill M.M., Andjelkovic M., Brazil D.P., Ferrari S., Fabbro D., Hemmings B.A., Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase, J. Biol. Chem., 276: 2564325646, 2001.
  • 41
    Delcommenne M., Tan C., Gray V., Rue L., Woodgett J., Dedhar S., Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and Akt/PKB by the integrin-linked kinase, Proc. Natl. Acad. Sci. USA., 95: 1121111216, 1998.
  • 42
    Lynch D.K., Ellis C.A., Edwards P.A., Hiles I.D., Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism, Oncogene, 18: 80248032, 1999.
  • 43
    Persad S., Attwell S., Gray V., Mawji N., Deng J.T., Leung D., Yan J., Sanghera J., Walsh M.P., Dedhar S., Regulation of Akt/PKB-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343, J. Biol. Chem., 276: 2746227469, 2001.
  • 44
    Chen R., Kim O., Yang J., Sato K., Eisenmann K.M., McCarthy J., Chen H., Qiu Y., Regulation of Akt/PKB activation by tyrosine phosphorylation, J. Biol. Chem., 276: 3185831862, 2001.
  • 45
    Sable C.L., Filippa N., Hemmings B., Van Obberghen E., cAMP stimulates protein kinase B in a Wortmannininsensitive manner, FEBS. Lett., 409: 253257, 1997.
  • 46
    Filippa N., Sable C.L., Filloux C., Hemmings B.A., Van Obberghen E., Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase, Mol. Cell Biol., 19: 49895000, 1999.
  • 47
    Perez-Garcia M.J., Cena V., De Pablo Y., Llovera M., Comella J.X., Soler R.M., Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway, J. Biol. Chem., 279: 61326142, 2004.
  • 48
    Konishi H., Matsuzaki H., Tanaka M., Takemura Y., Kuroda S., Ono Y., Kikkawa U., Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27, FEBS. Lett., 410: 493498, 1997.
  • 49
    Moule S.K., Welsh G.I., Edgell N.J., Foulstone E.J., Proud C.G., Denton R.M., Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and betaadrenergic agonists in rat epididymal fat cells. Activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms, J. Biol. Chem., 272: 77137719, 1997.
  • 50
    Brazil D.P., Park J., Hemmings B.A., PKB binding proteins: Getting in on the Akt, Cell, 111: 293303, 2002.
  • 51
    Maira S.M., Galetic I., Brazil D.P., Kaech S., Ingley E., Thelen M., Hemmings B.A., Carboxyl-terminal modulator protein (CTMP), a negative regulator of Akt/PKB and v-Akt at the plasma membrane, Science, 294: 374380, 2001.
  • 52
    Du K., Herzig S., Kulkarni R.N., Montminy M., TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver, Science, 300: 15741577, 2003.
  • 53
    Paramio J.M., Segrelles C., Ruiz S., Jorcano J.L., Inhibition of protein kinase B (PKB) and PKC-mediates keratin K10-induced cell cycle arrest, Mol. Cell Biol., 21: 74497459, 2001.
  • 54
    Konishi H., Matsuzaki H., Tanaka M., Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27, FEBS. Lett., 410: 493498, 1997.
  • 55
    Rane M.J., Pan Y., Singh S., Powell D.W., Wu R., Cummins T., Chen Q., McLeish K.R., Klein J.B., Heat shock protein 27 controls apoptosis by regulating Akt activation, J. Biol. Chem., 278: 2782827835, 2003.
  • 56
    Solit D.B., Basso A.D., Olshen A.B., Scher H.I., Rosen N., Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol, Cancer Res., 63: 21392144, 2003.
  • 57
    Han D.C., Shen T.L., Guan J.L., The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions, Oncogene, 20: 63156321, 2001.
  • 58
    Jahn T., Seipel P., Urschel S., Peschel C., Duyster J., Role for the adaptor protein Grb 10 in the activation of Akt, Mol. Cell Biol., 22: 979991, 2002.
  • 59
    Pekarsky Y., Koval A., Hallas C., Bichi R., Tresini M., Malstrom S., Russo G., Tsichlis P., Croce C.M., Tcll enhances Akt kinase activity and mediates its nuclear translocation, Proc. Natl. Acad. Sci. USA., 97: 30283303, 2000.
  • 60
    Auguin D., Barthe P., Royer C., Stern M.H., Noguchi M., Arold S.T., Roumestand C., Structural basis for the coactivation of protein kinase B by T-cell leukemia-1 (TCL1) family proto-oncoproteins, J. Biol. Chem., 279: 3589035902, 2004.
  • 61
    Remy I., Michnick S.W., Regulation of apoptosis by the Ft 1 protein, a new modulator of Akt/PKB, Mol. Cell Biol., 24: 14931504, 2004.
  • 62
    Cenni V., Sirri A., Riccio M., Lattanzi G., Santi S., De Pol A., Maraldi N.M., Marmiroli S., Targeting of the Akt/PKB kinase to the actin skeleton, Cell Mol. Life Sci., 60: 271027120, 2003.
  • 63
    Sinha D., Bannergee S., Schwartz J.H., Lieberthal W., Levine J.S., Inhibition of ligand-independent ERK1/2 activity in kidney proximal tubular cells deprived of soluble survival factors upregulates Akt and prevents apoptosis, J. Biol. Chem., 279: 1096210972, 2003.
  • 64
    Kim A.H., Yano H., Cho H., Meyer D., Monks B., Margolis B., Birnbaum M.J., Chao M.V., Akt 1 regulates a JNK scaffold during excitotoxic apoptosis, Neuron, 35: 697709, 2002.
  • 65
    van den Heuvel A.P., De Vries-Smits A.M., Van Weeren P.C., Dijkers P.F., De Bruyn K.M., Riedl J.A., Burgering B.M., Binding of protein kinase B to the plakin family member periplakin, J. Cell Sci., 115: 39573966, 2002.
  • 66
    Figueroa C., Tarras S., Taylor J., Vojtek A.B., Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex, J. Biol. Chem., 278: 4792247927, 2003.
  • 67
    Yao R., Cooper G.M., Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor, Science, 267: 20032006, 1995.
  • 68
    Bao S.D., Ouyang G.L., Bai X.F., Huang Z., Ma C., Liu M., Shao R., Anderson R.M., Rich J.N., Wang X.F., Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway, Cancer Cell, 5: 329339, 2004.
  • 69
    Shi Q, Bao SD, Maxwell JA, Reesel E.D., Friedmanl H.F., Bigner D.D., Wang X. F., Richl J.N., Secreted Protein Acidic, Rich in Cysteine (SPARC) Mediates Cellular Survival of Gliomas through AKT Activation, J. Biol. Chem., 279: 5220052209, 2004.
  • 70
    Gupta D., Syed N.A., Roesler W.J., Khandelwal R.L., Effect of overexpression and nuclear translocation of constitutively active PKB-alpha on cellular survival and proliferation in HepG2 cells, J. Cell Biochem., 93: 513, 2004.
  • 71
    Wendel H.G., De Stanchina E., Fridman J.S., Malina A., Ray S., Kogan S., Cordon-Cardo C., Pelletier J., Lowe S.W., Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy, Nature, 428: 332337, 2004.
  • 72
    Thornberry N.A., Lazebnik Y., Caspases: Enemies within, Science, 281: 312316, 1998.
  • 73
    Adams J.M., Cory S., The Bcl-2 protein family: Arbiters of cell survival, Science, 281: 13221326, 1998.
  • 74
    Del Peso L., Gonzalez-Garcia M., Page C., Herrera R., Nunez G., Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt, Science, 278: 687689, 1997.
  • 75
    Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., Greenberg M.E., Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery, Cell, 91: 231241, 1997.
  • 76
    Datta S.R., Brunet A., Greenberg M.E., Cellular survival: a play in three Akts, Genes Dev., 13: 29052927, 1999.
  • 77
    Donepudi M., Grutter M.G., Structure and zymogen activation of caspases, Biophys. Chem., 145153, 2002.
  • 78
    Cardone M.H., Roy N., Stennicke H.R., Salvesen G.S., Franke T.F., Stanbridge E., Frisch S., Reed J.C., Regulation of cell death protease caspase-9 by phosphorylation, Science, 282: 13181321, 1998.
  • 79
    Fujita E., Jinbo A., Matuzaki H., Konishi H., Kikkawa U., Momoi T., Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9, Biochem. Biophys. Res. Commun., 264: 550555, 1999.
  • 80
    Johnson G.L., Lapadat R., Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases, Science, 298: 19111912, 2002.
  • 81
    Kim A.H., Khursigara G., Sun X., Franke T.F., Chao M.V., Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1, Mol. Cell Biol., 21: 893901, 2001.
  • 82
    Barthwal M.K., Sathyanarayana P., Kundu C.N., Rana B., Pradeep A., Sharma C., Woodgett J.R., Rana A., Negative regulation of mixed lineage kinase 3 by Akt/PKB leads to cell survival, J. Biol. Chem., 278: 38973902, 2003.
  • 83
    Park H.S., Kim M.S., Huh S.H., Park J., Chung J., Kang S.S., Choi E.J., Akt (protein kinase B) negatively regulates SEK 1 by means of protein phosphorylation, J. Biol. Chem., 277: 25732578, 2002.
  • 84
    Paradis S., Ruvkun G., Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor, Genes Dev., 12: 24882498, 1998.
  • 85
    Burgering B.M., Medema R.H., Decisions on life and death: FOXO Forkhead transcription factors are in command when Akt/PKB is off duty, J. Leukoc. Biol., 73: 689701, 2003.
  • 86
    Li Q., Verma I.M., NF-KB regulation in the immune system, Nat. Rev. Immunol., 2: 725734, 2000.
  • 87
    Kane L.P., Shapiro V.S., Stokoe D., Weiss A., Induction of NF-kappaB by the Akt/PKB kinase, Curr. Biol., 9: 601604, 1999.
  • 88
    Barkett M., Gilmore T.D., Control of apoptosis by Rel/NF-KB transcription factors, Oncogene, 18: 69106924, 1999.
  • 89
    Lauder A., Castellanos A., Weston K., c-Myb transcription is activated by protein kinase B (PKB) following interleukin 2 stimulation of T cells and is required for PKB-mediated protection from apoptosis, Mol. Cell Biol., 21: 57975805, 2001.
  • 90
    Shimizu H., Hupp T.R., Intrasteric regulation of MDM2, Trends Biochem. Sci., 28: 346349, 2003.
  • 91
    Oren M., Decision making by p53: life, death and cancer, Cell Death Differ., 10: 431442, 2003.
  • 92
    Mayo L.D., Donner D.B., A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus, Proc. Natl. Acad. Sci. USA., 98: 1159811603, 2001.
  • 93
    Gottlieb T.M., Leal J.F., Seger R., Taya Y., Oren M., Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis, Oncogene, 21: 12991303, 2002.
  • 94
    Du K., Montminy M., CREB is a regulatory target for the protein kinase Akt/PKB, J. Biol. Chem., 273: 3237732379, 1998.
  • 95
    Wang J.M., Chao J.R., Chen. W., FKuo M.L., Yen J.J., Yang-Yen H.F., The antiapoptotic gene mcl-l is up-regulated by the phsophatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB, Mol. Cell Biol., 19: 61957206, 1999.
  • 96
    Basu S., Totty N.F., Irwin M.S., Sudol M., Downward J., Akt phosphoralates the Yet-associated protein, YAP, to induce interaction with 14-3-3 and attenuatin of p73-mediated apoptosis, Mol. Cell, 11: 1123, 2003.
  • 97
    Cross D.A., Alessi D.R., Cohen P., Andjelkovich M., Hemmings B.A., Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B, Nature, 378: 785789, 1995.
  • 98
    Doble B.W., Woodgett J.R., GSK-3: tricks of the trade for a multi-tasking kinase, J. Cell Sci., 116: 11751186, 2003.
  • 99
    Pap M., Cooper G.M., Role of glycogen synthase kinase-3 in the phosphatidylinsitol 3-kinase/Akt cell survival pathway, J. Biol. Chem., 273: 1992919932, 1998.
  • 100
    Rathmell J.C., Vander Heiden M.G., Harris M.H., Frauwirth K.A., Thompson C.B., In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability, Mol. Cell, 6: 683692, 2000.
  • 101
    Edinger A.L., Thompson C.B., Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake, Mol. Biol. Cell, 13: 22762288, 2002.
  • 102
    Vander Heiden M.G., Plas D.R., Rathmell J.C., Fox C.J., Harris M.H., Thompson C.B., Growth factors can influence cell growth and survival through effects on glucose metabolism, Mol. Cell Biol., 21: 58995912, 2001.
  • 103
    Rathmell J.C., Fox C.J., Plas D.R., Hammerman P.S., Cinalli R.M., Thompson C.B., Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival, Mol. Cell Biol., 23: 73157328, 2003.
  • 104
    Chun K.H., Kosmeder J.W. 2nd, Sun S., Pezzuto J.M., Lotan R., Hong W.K., Lee H.Y., Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells, J. Natl. Cancer Inst., 95: 291302, 2003.
  • 105
    Lee H.Y., Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells, Biochem. Pharmacol., 68: 11191124, 2004.