• 1
    Ripamonti, U. Osteogenic proteins of the TGF-β superfamily. In: Henry, HL, Norman, AW, editors. Encyclopedia of Hormones. Austin Academic Press; 2004. p. 806.
  • 2
    Ripamonti, U. Soluble, insoluble and geometric signals sculpt the architecture of mineralized bone. J Cell Mol Med. 2004; 8: 16980.
  • 3
    Ripamonti, U. Molecular signals in geometrical cues sculpt bone morphology. S Afr J Sci 2004; 100: 35567.
  • 4
    Wozney, JM, Rosen, V, Celeste, AJ, Mitsock, LM, Whitters, MJ, Kriz, RW, Hewick, RM, Wang, EA. Novel regulators of bone formation: Molecular clones and activities. Science 1988; 242: 152834.
  • 5
    Reddi, AH. Bone and cartilage differentiation. Curr Opin Genet Dev. 1994; 4: 73744.
  • 6
    Reddi, AH. Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nature Biotechnol. 1998; 16: 24752.
  • 7
    Reddi, AH. Morphogenesis and tissue engineering of bone and cartilage: Inductive signals, stem cells, and biomimetic biomaterials. Tissue Eng. 2001; 6: 35159.
  • 8
    Ripamonti, U, Ramoshebi, LN, Matsaba, T, Tasker, J, Crooks, J, Teare, J. Bone induction by BMPs/OPs and related family members in primates. The critical role of delivery systems. J Bone Joint Surg. 2001; 83-A: S1: 11627.
  • 9
    Ripamonti, U, Ramoshebi, LN, Patton, J, Matsaba, T, Teare, J, Renton, L. Soluble signals and insoluble substrata: Novel molecular cues instructing the induction of bone. In EJMassaro and JMRogers (Eds.) The Skeleton. Humana Press, Chapter 15, 2004. p. 21727.
  • 10
    Reddi, AH. Bone morphogenetic proteins: An unconventional approach to isolation of first mammalian morphogens. Cytokine Growth Factor Rev 1997; 8: 1120.
  • 11
    Sampath, TK, Rashka, KE, Doctor, JS, Tucker, RF, Hoffmann, FM. Drosophila TGF-β superfamily proteins induce endochondral bone formation in mammals. Proc Natl Acad Sci USA 1993; 90: 60048.
  • 12
    Sampath, TK, Maliakal, JC, Hauschka, PV, Jones, WK, Sasak, H, Tucker, RF, White, KH, Coughlin, JE, Tucker, MM, Pang, RH, et al. Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro. J Biol Chem 1992; 267: 2035262.
  • 13
    Ripamonti, U, van den Heever, B, Crooks, J, Rueger, DC, Reddi, AH. Long-term evaluation of bone formation by osteogenic protein 1 in the baboon and relative efficacy of bone-derived bone morphogenetic proteins delivered by irradiated xenogeneic collagenous matrices. J Bone Miner Res 2000; 15: 1798809.
  • 14
    Sampath, TK, Reddi, AH. Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation. Proc Natl Acad Sci USA 1981; 78: 7599603.
  • 15
    Wang, H, Springer, IN, Schildberg, H, Ludwig, K, Rueger, DC, Terheyden, H. Carboxymethylcellulose-stabilized collagenous rhOP-1 device - a novel carrier biomaterial for the repair of mandibular continuity defects. J Biomed Mater Res 2004; 68: 21926.
  • 16
    Duneas, N, Crooks, J, Ripamonti, U. Transforming growth factor-β1: Induction of bone morphogenetic protein genes expression during endochondral bone formation in the baboon, and synergistic interaction with osteogenic protein-1 (BMP-7). Growth Factors 1998; 15: 25977.
  • 17
    Ripamonti, U, Crooks, J, Matsaba, T, Tasker, J. Induction of endochondral bone formation by recombinant human transforming growth factor-β2 in the baboon (Papio ursinus). Growth Factors 2000; 17: 26985.
  • 18
    de Rynk, R, Jarret, JA, Chen, EY, Eaton, EH, Bell, JR, Assoian, RK, Roberts, AB, Sporn, MB, Goeddel, DV. Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells. Nature 1985; 316: 7015.
  • 19
    Hostikka, SL, Tryggvason, K. The complete primary structure of the α2 chain of the human type IV collagen and comparison with the α (IV) chain. J Biol Chem 1988; 263: 1948893.
  • 20
    Özkaynak, E, Rueger, DC, Drier, EA, Corbett, C, Ridge, RJ, Samapth, T, Oppermann, H. OP-1 cDNA encodes an osteogenic protein in the TGF-β family. Embo J Org 1990; 9: 208593.
  • 21
    Helder, MN, Özkaynak, E, Sampath, KT, Luyten, FP, Latin, V, Oppermann, H, Vukicevic, S. Expression of osteogenic protein-1 (bone morhogenetic protein-7) in human mouse development. J Histochem Cytochem 1995; 43: 103544.
  • 22
    Ripamonti, U. Bone induction in nonhuman primates. An experimental study on the baboon (Papio ursinus). Clin Orthop Rel Res 1991; 269: 28494.
  • 23
    Public Service Department. National Code for Animal Use in Research Education, Diagnosis and Testing of Drugs and Related Substances in South Africa. Public Service Department, Pretoria , South Africa 1990.
  • 24
    Ripamonti, U, Ma, S, Cunningham, N, Yates, L, Reddi, AH. Initiation of bone regeneration in adult baboons by osteogenin, a bonemorphogenetic protein. Matrix 1992; 12: 36980.
  • 25
    Ripamonti, U, Ma, S, Cunningham, N, Yeates, L, Reddi, AH. Reconstruction of bone-bone marrow organ by osteogenin, a bone morphogenetic protein, and demineralized bone matrix in calvarial defects of adult primates. Plast Reconstr Surg 1993; 91: 26367.
  • 26
    Ripamonti, U, van den Heever, B, Sampath, TK, Tucker, MM, Rueger, DC, Reddi, AH. Complete regeneration of bone in the baboon by recombinant human osteogenic protein-1 (hOP-1, bone morphogenetic protein-7). Growth Factors 1996; 13: 27389.
  • 27
    Parfitt, AM. Stereologic basis of bone histomorphometry; theory of quantitative microscopy and reconstruction of the third dimension. In: Recker, RR (ed). Bone Histomorphometry: Techniques and Interpretation. CRC Press, Boca Raton , FL USA p 5387.
  • 28
    Parfitt, AM, Drezner, MK, Gliorieux, FH, Kanis, JA, Malluche, H, Meunier, PJ, Ott, SM, Recker, RR. Bone histomorphometry: Standardization of nomenclature, symbols, and units. J Bone Miner Res 1987; 2: 595610.
  • 29
    Ripamonti, U, Duneas, N, van den Heever, B, Bosch, C, Crooks, J. Recombinant transforming growth factor-β1 induces endochondral bone in the baboon and synergizes with recombinant osteogenic protein-1 (bone morphogenetic protein-7) to initiate rapid bone formation. J Bone Miner Res 1997; 2: 158495.
  • 30
    Statistical Analysis System. SAS/STATS User's Guide, version 6, 4th ed. Vol 1. SAS Institute, Inc., Cary , NC , USA , 1989. p. 20944.
  • 31
    Roman-Roman, S, Garcia, T, Jackson, A, Theilhabr, J, Rawadi, G, Connolly, T, Spinella-Jaegle, S, Kawai, S, Courtois, B, Bushnell, S, Auberval, M, Call, K, Baron, R. Identification of genes regulated during osteoblastic differentiation by genome-wide expression analysis of mouse calvaria primary osteoblasts in vitro Bone 2003; 32: 47482.
  • 32
    Cho, T, Gerstenfeld, L, Einhorn, T. Differential temporal expression of multiple members of TGF β superfamily during murine bone healing. 47th Annual Meeting, Orthopaedic Research Society, February 25–28, San Francisco, California. 2001.
  • 33
    Spector, J.A, Luchs, J.S., Mehrara, B.J, Greenwald, JA, Smith, LP, Longaker, MT. Expression of bone morphogenetic proteins during membranous bone healing. Plast Reconstr Surg 2001; 107: 12434.
  • 34
    Yeh, LC, Unda, R, Lee, JC. Osteogenic protein-1 differentially regulates the mRNA expression of bone morphogenetic proteins and their receptors in primary cultures of osteoblasts. J Cell Physiol 2000; 185: 8797.
  • 35
    Bahamonde, M. E, Lyons, K. M. BMP3: To be or not to be a BMP. J Bone Joint Surg 2001; 83-A: S1: 5662.
  • 36
    Chen, D, Harris, MA, Rossini, G, Dunstan, CR, Dallas, SL, Feng, JQ, Mundy, GR, Harris, SE. Bone morphogenetic protein 2 (BMP-2) enhances BMP-3, BMP-4, and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts. Calcif Tissue Int 1997; 60: 28390.
  • 37
    Honda, Y, Knutsen, R, Strong, DD, Sampath, TK, Baykink, DJ, Mohan, S. Osteogenic protein-l stimulates mRNA levels of BMP-6 and decreases mRNA levels of BMP-2 and −4 in human osteosarcoma cells. Calcif Tissue Int 1997; 60: 297301.
  • 38
    Ripamonti, U, Herbst, N-N, Ramoshebi, KN. Bone morphogenetic proteins in craniofacial and periodontal tissue engineering: Experimental studies in the non-human primate Papio ursinus. Cytokine Growth Factors Rev 2005; 16: 35768.
  • 39
    Ramoshebi, LN, Ripamonti, U. Osteogenic protein-l, a bone morphognetic protein, induces angiogenesis in the chick chorioallantoic membrane and synergizes wiht basic fibroblast growth factor and transforming growth factor- β. Anat Record. 2000; 259: 97107.
  • 40
    Folkman, J, Klagsbrun, M, Sasse, J, Wadzinski, M, Ingber, D, Wlodavsky, I. A heparin-bind angiognic protein-basic fibroblast growth factor-is stored within basement membranes. Am J Pathol. 1988; 130: 393400.
  • 41
    Wlodavsky, I, Folkman, J, Sullivan, R, Fridman, R, Ishai-Michaeli, R, Klagsbrun, M. Endothelial cell-dervied basic fibroblast growth factor. Synthesis and deposition into subendothelial extracellular matrix. proc Natl Acad Sci USA. 1987; 84: 229296.
  • 42
    Paralkar, VM, Nandekar, AKN, Pointer, RH, Kleinman, HK, Reddi, AH. Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen. J Biol Chem 1990; 265: 178184.
  • 43
    Paralkar, VM, Vukicevic, S, Reddi, AH. Transforming growth factor β typel binds to collagen type IV of basement membrane matrix: Implication for development. Dev Biol. 1991; 143: 3038.
  • 44
    de Ckers, MML, Rutger, L, van Bezooijen, RL, van der Horst, G, Hoogendam, J, van der Bent, C, Papapoulus, Löwik CWGM. Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vasculalr endothelial growth factor A. Endocrinology 143: 154553.
  • 45
    Tabibzadeh, S, Kothapalli, R, Buyuksal, I. Distinct tumor specific expression of TGFβ4 (ebaf), an novel human geme of the TGF-β superfamily. Front Biosci. 1997; 2: 1825.
  • 46
    Kothapalli, R, Buyukasal, I, Wu, S-Q, Chegini, N, Tabibzadeh, S. Detection of ebaf, a novel human gene of the transforming growth factor β superfamily. Association of gene expression with endometrial bleeding. J Clin Invest. 1997; 99: 234250.