• Open Access

CD117/c-kit positive interstitial (Cajal-like) cells in human pancreas

Authors

  • L.M. Popescu,

    Corresponding author
    1. Department of Cellular and Molecular Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
    2. “Victor Babes” National Institute of Pathology, Bucharest, Romania
      *Correspondence to: L.M. POPESCU, M.D., Ph.D. Department of Cellular and Molecular Medicine, “Carol Davila” University of Medicine and Pharmacy, P.O. Box 35-29, Bucharest 35, Romania. Tel: +40(0)744 535 298; Fax: +40(0)21-312 4885 E-mail: LMP@univermed-cdgm.ro
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  • M.E. Hinescu,

    1. Department of Cellular and Molecular Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
    2. “Victor Babes” National Institute of Pathology, Bucharest, Romania
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  • E. Radu,

    1. Department of Cellular and Molecular Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
    2. “Victor Babes” National Institute of Pathology, Bucharest, Romania
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  • Sanda M. Ciontea,

    1. Department of Cellular and Molecular Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
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  • D. Cretoiu,

    1. Department of Cellular and Molecular Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
    2. “Victor Babes” National Institute of Pathology, Bucharest, Romania
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  • M. Leabu,

    1. Department of Cellular and Molecular Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
    2. “Victor Babes” National Institute of Pathology, Bucharest, Romania
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  • Carmen Ardeleanu

    1. “Victor Babes” National Institute of Pathology, Bucharest, Romania
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*Correspondence to: L.M. POPESCU, M.D., Ph.D. Department of Cellular and Molecular Medicine, “Carol Davila” University of Medicine and Pharmacy, P.O. Box 35-29, Bucharest 35, Romania. Tel: +40(0)744 535 298; Fax: +40(0)21-312 4885 E-mail: LMP@univermed-cdgm.ro

Abstract

We provide evidence that interstitial Cajal-like cells, previously described in human pancreas - pICC (J Cel Mol Med, 9: 169, 2005), are positive for c-kit irrespective of immunohistochemical procedures used. Various sample types (fresh cryosections or formalin-fixed, paraffin-embedded specimens), various slide pretreatments (with or without heat-induced epitope retrieval) or different antibodies used (Dako polyclonal or Santa Cruz monoclonal), all showed CD117-positive pICC.

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