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Stem Cells Review Series
Systems biology and cancer stem cells
Article first published online: 20 NOV 2007
DOI: 10.1111/j.1582-4934.2007.00151.x
2008 The Institute for Systems Biology Journal compilation © 2008 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd
Issue
Journal of Cellular and Molecular Medicine
Volume 12, Issue 1, pages 97–110, January/February 2008
Additional Information
How to Cite
Price, N. D., Foltz, G., Madan, A., Hood, L. and Tian, Q. (2008), Systems biology and cancer stem cells. Journal of Cellular and Molecular Medicine, 12: 97–110. doi: 10.1111/j.1582-4934.2007.00151.x
Publication History
- Issue published online: 20 NOV 2007
- Article first published online: 20 NOV 2007
- Received: June 15, 2007; Accepted: August 25, 2007
- Abstract
- Article
- References
- Cited By
Keywords:
- transcriptomics;
- proteomics;
- molecular signature;
- networks
- • Introduction
- • Molecular profiling for cancer classification
- • Molecular profiling of cancer stem cells
- - Historical perspective: cancer stem cells in leukaemia
- - Molecular profiling of brain cancer stem cells
- - Molecular profiling of breast cancer stem cells
- -
- • Emerging technologies for proteome characterization
- - Isobaric tagging for relative and absolute quantitation (iTRAQ)
- - Glyco-peptide capture
- - Antibody microarrays using surface plasmon Resonance imaging (SPRI)
- - DNA-enabled antibody libraries (DEAL)
- -
- • Biomolecular networks in cancer
- • Perspective and concluding remarks
Abstract
The identification, purification and characterization of cancer stem cells (CSCs) holds tremendous promise for improving the treatment of cancer. Mounting evidence is demonstrating that only certain tumour cells (i.e. the CSCs) can give rise to tumours when injected and that these purified cell populations generate heterogeneous tumours. While the cell of origin is still not determined definitively, specific molecular markers for populations containing these CSCs have been found for leukaemia, brain cancer and breast cancer, among others. Systems approaches, particularly molecular profiling, have proven to be of great utility for cancer diagnosis and characterization. These approaches also hold significant promise for identifying distinctive properties of the CSCs, and progress is already being made.