• Open Access

Molecular mechanism of regulation of the calcium-binding protein calbindin-D9k,and its physiological role(s) in mammals: a review of current research

Authors

  • Kyung-Chul Choi,

    1. Department of Obstetrics and Gynecology, Faculty of Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
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  • Eui-Bae Jeung

    Corresponding author
    1. Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
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*Correspondence to: Dr. Eui-Bae JEUNG,
Laboratory of Veterinary Biochemistry and
Molecular Biology, College of Veterinary Medicine,
Chungbuk National University, Cheongju,
Chungbuk, 361–763, Republic of Korea.
Tel.:+82-43-261-2397
Fax:+82-43-267-3150
E-mail: ebjeung@chungbuk.ac.kr

Abstract

  • • Introduction
  • • Phenotype of CaBP-9k knockout mouse
  • • Uterine expression and regulation of CaBP-9k
  • • Placental expression and regulation of CaBP-9k
  • • Duodenal and renal expression and regulation of CaBP-9k
  • • Pituitary expression and regulation of CaBP-9k
  • • Transcriptional regulation of CaBP-9k
  • • Conclusions

Abstract

Calbindin-D9k (CaBP-9k) is a cytosolic calcium-binding protein that is expressed in a variety of tissues, such as uterus, placenta, intestine, kidney, pituitary gland and bone. At present, the precise role(s) of CaBP-9k remains to be clarified. CaBP-9k-null mice are normal, which indicates that other calcium-transporter genes can compensate for the lack CaBP-9k. Uterine CaBP-9k has been shown to be involved in the regulation of myometrial activity by intracellular calcium. In the uterus and placenta, CaBP-9k expression is regulated by the sex steroid hormones oestrogen (E2) and progesterone (P4). Intestinal CaBP-9k is involved in intestinal calcium absorption, and is regulated at the transcriptional and post-transcriptional levels by 1,25-dihydroxyvitamin D3, the hormonal form of vitamin D. Thus, evidence to date suggests that CaBP-9k may be regulated in a tissue-specific manner. In this review, we will summarize current data on the molecular mechanism of regulation of CaBP-9k in mammals, including recent research data generated in our laboratories.

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