You have open access to this content
CD40 ligation restores type 1 polarizing capacity in TLR4-activated dendritic cells that have ceased interleukin-12 expression
Article first published online: 8 NOV 2008
DOI: 10.1111/j.1582-4934.2008.00584.x
© 2008 The Authors Journal compilation © 2009 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd
Total views since August 2010: 54
Additional Information
How to Cite
Michael Dohnal, A., Luger, R., Paul, P., Fuchs, D. and Felzmann, T. (2009), CD40 ligation restores type 1 polarizing capacity in TLR4-activated dendritic cells that have ceased interleukin-12 expression. Journal of Cellular and Molecular Medicine, 13: 1741–1750. doi: 10.1111/j.1582-4934.2008.00584.x
Publication History
- Issue published online: 26 NOV 2009
- Article first published online: 8 NOV 2008
- Received: June 20, 2008; Accepted: October 24, 2008
- Abstract
- Article
- References
- Cited By
- Cumulative Usage
References
- 1, . Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol. 2006; 311: 17–58.
- 2, . Toll-like receptor signalling. Nat Rev Immunol. 2004; 4: 499–511.
- 3. Tolerance, danger, and the extended family. Ann Rev Immunol. 1994; 12: 991–1045.
- 4, , , et al . Semi-mature IL-12 secreting dendritic cells present exogenous antigen to trigger cytolytic immune responses. Cancer Immunol Immunother. 2005; 54: 769–80.
- 5, , , et al . Generation of potent anti-tumor immunity in mice by interleukin-12-secreting dendritic cells. Cancer Immunol Immunother. 2005; 54: 67–77.
- 6, , , et al . Phase I study of tumor Ag-loaded IL-12 secreting semi-mature DC for the treatment of pediatric cancer. Cytotherapy. 2007: 1–16.
- 7, , , et al . Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat Immunol. 2000; 1: 3116.
- 8, . IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol. 2004; 4: 762–74.
- 9, , , et al . IDO expands human CD4+CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells. Eur J Immunol. 2007; 37: 3054–62.
- 10, . The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 2004; 25: 280–8.
- 11, . The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol. 2007; 7: 353–64.
- 12, , . Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature. 2007; 447: 972–8.
- 13, , , et al . The plasticity of dendritic cell responses to pathogens and their components. Science. 2001; 294: 870–5.
- 14, , , et al . Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science. 2005; 309: 1854–7.
- 15. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol. 2003; 3: 133–46.
- 16, , . Post-proteasomal antigen processing for major histocompatibility complex class I presentation. Nat Immunol. 2004; 5: 670–7.
- 17. Immunology. Licence to kill. Nature. 1998; 393: 413–4.
- 18, , , et al . Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature. 1998; 393: 478–80.
- 19, , . A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature. 1998; 393: 474–8.
- 20, , , et al . T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature. 1998; 393: 480–3.
- 21, , . Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol. 2001; 2: 725–31.
- 22, , , et al . Comparative evaluation of techniques for the manufacturing of dendritic cell-based cancer vaccines. J Cell Mol Med. 2009; 13: 125–35.
- 23, , , et al . Detection of N-myc gene amplification by fluorescence in situ hybridization. Diagnostic utility for neuroblastoma. Am J Pathol. 1993; 142: 1339–46.
- 24, , , et al . More rapid method for simultaneous measurement of tryptophan and kynurenine by HPLC. Clin Chem. 2002; 48: 579–81.
- 25, . Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol. 2007; 7: 19–30.
- 26, , , et al . Duration, combination and timing: the signal integration model of dendritic cell activation. Trends Immunol. 2007; 28: 227–33.
- 27, . CD28-B7 bidirectional signaling: a two-way street to activation. Nat Immunol. 2004; 5: 1103–5.
- 28. On watching the watchers: IDO and type I/II IFN. Eur J Immunol. 2007; 37: 876–9.
- 29, . Endotoxin tolerance: a review. Crit Care Med. 2002; 30: S64–73.
- 30, , , et al . Final maturation of dendritic cells is associated with impaired responsiveness to IFN-{gamma} and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells. J Immunol. 1999; 162: 3231–6.
- 31, , , et al . Functional maturation of dendritic cells by exposure to CD40L transgenic tumor cells, fibroblasts or keratinocytes. Cancer Lett. 2001; 168: 145–54.
- 32, , , et al . Involvement of IL-10 in exhaustion of myeloid dendritic cells and rescue by CD40 stimulation. Immunology. 2007; 120: 28–37.

1582-4934/asset/olbannerleft.gif?v=1&s=9ac4fbc1c8dd6b354380356601e09fc12424db35)
1582-4934/asset/olbannerright.gif?v=1&s=cd3126c456d5857b7dbedcf7ab88bbd934f98dcc)
