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Figure S1. The inhibited ATP-binding site of Pak1. The kinase inhibitory (KI) segment of the autoregulatory fragment occupies the cleft between the small and the large lobes of the kinase domain. Lys141 makes hydrogen bonds with Asp407 of the activation loop. Therefore, the activation loop is forced to make a turn, which blocks the contact between Glu355 of Helix C and Lys299Arg and prevents binding of ATP. The hydrogen bonding interactions are shown as magenta-dotted lines.

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JCMM_605_sm_fS1.ppt418KSupporting info item

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