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Keywords:

  • hyperactivity;
  • plaque vicinity;
  • calcium dyshomeostasis;
  • seizure;
  • in vivo calcium imaging;
  • two-photon microscopy

Abstract

  • • 
    Introduction
  • • 
    Dysregulation of Ca2+ homeostasis in AD
    • - 
      Aβ accumulation causes Ca2+ dyshomeostasis
    • - 
      Ca2+ dyshomeostasis increases Aβ production
  • • 
    Presenilins and Ca2+ homeostasis
  • • 
    Dysregulation of Ca2+ homeostasis in vivo
  • • 
    AD-mediated hyperactivity and synaptic network dysfunction
  • • 
    Neuronal hyperactivity: implications for humans
  • • 
    Plaque vicinity
  • • 
    Conclusions

More than two decades ago, dysregulation of the intracellular Ca2+ homeostasis was suggested to underlie the development of Alzheimer’s disease (AD). This hypothesis was tested in numerous in vitro studies, which revealed multiple Ca2+ signalling pathways able to contribute to AD pathology. It remained, however, unclear whether these pathways are also activated in vivo, in cells involved in signal processing in the living brain. Here we review recent data analysing intracellular Ca2+ signalling in vivo in the context of previous in vitro findings. We particularly focus on the processes taking place in the immediate vicinity of amyloid plaques and on their possible role for AD-mediated brain dysfunction.