• Open Access

Mankind’s first natural stem cell transplant

Authors

  • Jose N. Tolosa,

    1. Department of Pediatrics, Division Neonatology, University of South Florida, College of Medicine, Tampa, FL, USA
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  • Dong-Hyuk Park,

    1. Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida, College of Medicine, Tampa, FL, USA
    2. Department of Neurosurgery, Korea University Medical Center, Korea University College of Medicine, Seoul, South Korea
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  • David J. Eve,

    1. Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida, College of Medicine, Tampa, FL, USA
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  • Stephen K. Klasko,

    1. Department of Obstetrics and Gynecology, University of South Florida, College of Medicine, Tampa, FL, USA
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  • Cesario V. Borlongan,

    1. Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida, College of Medicine, Tampa, FL, USA
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  • Paul R. Sanberg

    Corresponding author
    1. Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida, College of Medicine, Tampa, FL, USA
    2. Office of Research and Innovation, University of South Florida, Tampa, FL, USA
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Correspondence to: Paul R. SANBERG, Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair MDC 78, University of South Florida College of Medicine, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612, USA.
Tel.: 813-974-3154
Fax: 813-974-3078
E-mail: psanberg@health.usf.edu

Abstract

  • • Introduction
  • • Early haematopoiesis in foetus
  • • Early versus late clamping of the umbilical cord
  • • Stem cells in human umbilical cord blood
    • - Cellular composition
    • - Usefulness of umbilical cord blood stem cells
  • • First stem cell transplantation at birth
  • • Conclusions

The timing of the umbilical cord clamping at birth is still controversial. In the modern era of medicine, the cord has been clamped early to facilitate resuscitation and stabilization of infants. However, recently delayed cord clamping has been supported by physicians because it allows for the physiological transfer of blood from the placenta to the infant. Many clinical studies have revealed that the delayed cord clamping elevates blood volume and haemoglobin and prevents anaemia in infants. Moreover, since it was known that umbilical cord blood contains various valuable stem cells such as haematopoietic stem cells, endothelial cell precursors, mesenchymal progenitors and multipotent/pluripotent lineage stem cells, the merit of delayed cord clamping has been magnified. In this review, we discuss the advantages and disadvantages of delayed cord clamping at birth. We highlight the importance of delayed cord clamping in realizing mankind’s first stem cell transfer and propose that it should be encouraged in normal births.

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