• Open Access

Engineering skeletal muscle tissue – new perspectives in vitro and in vivo

Authors

  • Dorothee Klumpp,

    1. Department of Plastic and Hand Surgery, University Hospital of Erlangen, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany
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  • Raymund E. Horch,

    1. Department of Plastic and Hand Surgery, University Hospital of Erlangen, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany
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  • Ulrich Kneser,

    1. Department of Plastic and Hand Surgery, University Hospital of Erlangen, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany
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  • Justus P. Beier

    Corresponding author
    1. Department of Plastic and Hand Surgery, University Hospital of Erlangen, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany
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Correspondence to: Justus P. BEIER, M.D., Department of Plastic and Hand Surgery University Hospital of Erlangen Friedrich-Alexander-University of Erlangen-Nürnberg,
Krankenhausstr. 12D-91054 Erlangen Germany.
Tel.: +49-9131-8533296
Fax: +49-9131-8539327
E-mail: justus.beier@uk-erlangen.de

Abstract

  • • Introduction
  • • Matrices for skeletal muscle tissue engineering – gaining orientation
  • • Electrospun nanofibre matrices
  • • Nanotechnology and smart matrices
  • • Cell sources for skeletal muscle TE
  • • Conclusion

Muscle tissue engineering (TE) has not yet been clinically applied because of several problems. However, the field of skeletal muscle TE has been developing tremendously and new approaches and techniques have emerged. This review will highlight recent developments in the field of nanotechnology, especially electrospun nanofibre matrices, as well as potential cell sources for muscle TE. Important developments in cardiac muscle TE and clinical studies on Duchenne muscular dystrophy (DMD) will be included to show their implications on skeletal muscle TE.

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