These authors contributed equally to this work.
Systemic transplantation of human adipose-derived stem cells stimulates bone repair by promoting osteoblast and osteoclast function
Article first published online: 26 SEP 2011
© 2011 The Authors Journal of Cellular and Molecular Medicine © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd
Journal of Cellular and Molecular Medicine
Volume 15, Issue 10, pages 2082–2094, October 2011
How to Cite
Lee, K., Kim, H., Kim, J.-M., Kim, J.-R., Kim, K.-J., Kim, Y.-J., Park, S.-I., Jeong, J.-H., Moon, Y.-m., Lim, H.-S., Bae, D.-W., Kwon, J., Ko, C.-Y., Kim, H.-S., Shin, H.-I. and Jeong, D. (2011), Systemic transplantation of human adipose-derived stem cells stimulates bone repair by promoting osteoblast and osteoclast function. Journal of Cellular and Molecular Medicine, 15: 2082–2094. doi: 10.1111/j.1582-4934.2010.01230.x
- Issue published online: 26 SEP 2011
- Article first published online: 26 SEP 2011
- Accepted manuscript online: 15 DEC 2010 08:43AM EST
- Received: August 20, 2010; Accepted: November 2, 2010
- adipose-derived stem cell;
- systemic transplantation
Systemic transplantation of adipose-derived stem cells (ASCs) is emerging as a novel therapeutic option for functional recovery of diverse damaged tissues. This study investigated the effects of systemic transplantation of human ASCs (hASCs) on bone repair. We found that hASCs secrete various bone cell-activating factors, including hepatocyte growth factor and extracellular matrix proteins. Systemic transplantation of hASCs into ovariectomized mice induced an increased number of both osteoblasts and osteoclasts in bone tissue and thereby prevented bone loss. We also observed that conditioned medium from hASCs is capable of stimulating proliferation and differentiation of osteoblasts via Smad/extracellular signal-regulated kinase (ERK)/JNK (c-jun NH2-terminal kinase) activation as well as survival and differentiation of osteoclasts via ERK/JNK/p38 activation in vitro. Overall, our findings suggest that paracrine factors secreted from hASCs improve bone repair and that hASCs can be a valuable tool for use in osteoporosis therapy.