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Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation

  1. Meena Mahmood1,
  2. Zhiguang Li2,
  3. Daniel Casciano1,
  4. Mariya V. Khodakovskaya1,
  5. Tao Chen2,
  6. Alokita Karmakar1,
  7. Enkeleda Dervishi1,
  8. Yang Xu1,
  9. Thikra Mustafa1,
  10. Fumiya Watanabe1,
  11. Ashley Fejleh1,
  12. Morgan Whitlow1,
  13. Mustafa Al-Adami1,
  14. Anindya Ghosh3,
  15. Alexandru S. Biris1,*

Article first published online: 24 OCT 2011

DOI: 10.1111/j.1582-4934.2010.01234.x

Issue

Journal of Cellular and Molecular Medicine

Journal of Cellular and Molecular Medicine

Volume 15, Issue 11, pages 2297–2306, November 2011

Total views since publication: 121

Additional Information

How to Cite

Mahmood, M., Li, Z., Casciano, D., Khodakovskaya, M. V., Chen, T., Karmakar, A., Dervishi, E., Xu, Y., Mustafa, T., Watanabe, F., Fejleh, A., Whitlow, M., Al-Adami, M., Ghosh, A. and Biris, A. S. (2011), Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation. Journal of Cellular and Molecular Medicine, 15: 2297–2306. doi: 10.1111/j.1582-4934.2010.01234.x

Author Information

  1. 1

    University of Arkansas at Little Rock, Nanotechnology Center, Applied Science Department, Little Rock, AR, USA

  2. 2

    National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, U.S. Food and Drug Administration, Jefferson, AR, USA

  3. 3

    University of Arkansas at Little Rock, Chemistry Department, Nanotechnology Center, Little Rock, AR, USA

* Alexandru S. BIRIS, University of Arkansas at Little Rock, Nanotechnology Center, Applied Science Department, Little Rock, AR 72204, USA. Tel.: 1-(501) 683–7458 Fax: 1-(501) 683–7601 E-mail: asbiris@ualr.edu

Publication History

  1. Issue published online: 24 OCT 2011
  2. Article first published online: 24 OCT 2011
  3. Accepted manuscript online: 9 DEC 2010 06:38AM EST
  4. Received: August 27, 2010; Accepted: November 25, 2010

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Keywords:

  • nanomaterials;
  • bone cells;
  • mineralization;
  • miRNA regulation

Abstract

We report that several nanomaterials induced enhanced mineralization (increased numbers and larger areas of mineral nests) in MC3T3-E1 bone cells, with the highest response being induced by silver nanoparticles (AgNPs). We demonstrate that AgNPs altered microRNA expression resulting in specific gene expression associated with bone formation. We suggest that the identified essential transcriptional factors and bone morphogenetic proteins play an important role in activation of the process of mineralization in bone cells exposed to AgNPs.

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