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Fig. S1 The secondary structure of 5′-region of MDR1 mRNA is shown and the twelve R-Y dinucleotides on the surface of the MDR1 mRNA secondary structure were selected as targets for DRzs.

Fig. S2 (A) Anti-miR-27a inhibitor and ASODN could only suppress Pgp expression at concentration of 5 μg/ml or above (P < 0.05). However, DRz 3 could suppress it at concentrations of 0.5 μg/ml or above, in a dose-dependent response in MDA/ADR cells. (B) During the continuous observations of DRz at 5 μg/ml, the inhibitory effect of DRz 3 on Pgp expression was better and longer than that for the other two groups in MDA/ADR cells (P < 0.05).

Fig. S3 Rh123 retention showed that intracellular Rh123 in cells treated with DRz 3 was significantly higher than that of the other two groups in MDA-7/ADR cells.

Table S1 Fold change of MDR1 mRNA and chemosensitivity assay in MDA/ADR cells transfected with DRzs

Table S2 Cell toxicity of DRz 3, ASODN, ribozyme and anti-miR-27a inhibitor

Table S3 Evaluation of chemosensitivity in the transfected MDA/ADR cells

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