• Open Access

miR-193 expression differentiates telocytes from other stromal cells

Authors

  • V.B. Cismasiu,

    1. Department of Cellular and Molecular Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, Bucharest, Romania
    2. Department of Advanced Studies and Pico & Nanotechnology, ‘Victor Babeṣ’ National Institute of Pathology, Bucharest, Romania
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    • These authors contributed equally to this work.

  • E. Radu,

    1. Department of Cellular and Molecular Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, Bucharest, Romania
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    • These authors contributed equally to this work.

  • L.M. Popescu

    Corresponding author
    1. Department of Cellular and Molecular Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, Bucharest, Romania
    2. Department of Advanced Studies and Pico & Nanotechnology, ‘Victor Babeṣ’ National Institute of Pathology, Bucharest, Romania
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Correspondence to: L.M. POPESCU, M.D., Ph.D., Department of Advanced Studies and Pico & Nanotechnology, ‘Victor Babeş’ National Institute of Pathology, Splaiul Independentei 99–101, 050096 Bucharest, Romania.
E-mail: lmp@jcmm.org

Abstract

Telocytes (TCs) are a particular type of interstitial (stromal) cells defined by very long, moniliform telopodes. Their tissue location, between blood vessels and other cells such as cardiomyocytes (CMC) and neurons, suggests a role in intercellular signalling. In order to define a microRNA (miR) signature in cardiac TCs, we have found that miR-193 is differentially expressed between TCs and other interstitial cells. Because miR-193 regulates c-kit, our data support the previous finding that TCs express c-kit in certain circumstances. In addition, the miRs which are specific to CMC and other muscle cells (e.g. miR-133a, miR-208a) are absent in TCs. Overall the data reinforce the view that TCs are a particular type of interstitial (mesenchymal) cells.

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