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jcmm1596-sup-0001-FigS1.docxWord document72KFig. S1 Dose response, time curve and cholinergic involvement of the fluoxetine-mediated vasodilation effect (A) Arteriolar diameter presented as percentage from control (averages ± S.D. for 5 points along an arteriole) following perfusion of 5–100 µM fluoxetine. Note the faster response under 100 µM. (B) Arteriolar diameter presented as percentage from control (averages ± S.D. for 5 points along an arteriole) following perfusion of 50 µM carbachol (right structure).
jcmm1596-sup-0002-FigS2.docWord document323KFig. S2 Atropine suppresses fluoxetine-mediated vasodilation selectively but does not prevent the bradykinin effect (A) Representative images of pial arterioles in the rat cerebral cortex. Shown are photographs after applying the noted compounds. Note that atropine blocks the effects of 500 µM fluoxetine, but not of 100 µM bradikinin. (B) Schematic presentation of our working hypothesis; atropine selectively antagonizes endothelial muscarinic receptors and fluoxetine, but not bradikinin-mediated vasodilation is suppressed. Activation of either of these receptors increases intracellular Ca2+ levels and facilitates the production of NO from l-arginine by eNOS while bradikinin induces vasodilatation via cyclooxygenase-1 (COX1) as well.

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