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Original Article
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Akt- and Erk-mediated regulation of proliferation and differentiation during PDGFRβ-induced MSC self-renewal
Article first published online: 29 OCT 2012
DOI: 10.1111/j.1582-4934.2012.01602.x
© 2012 The Authors Journal of Cellular and Molecular Medicine © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd
Total views since publication: 273
Additional Information
How to Cite
Gharibi, B., Ghuman, M. S. and Hughes, F. J. (2012), Akt- and Erk-mediated regulation of proliferation and differentiation during PDGFRβ-induced MSC self-renewal. Journal of Cellular and Molecular Medicine, 16: 2789–2801. doi: 10.1111/j.1582-4934.2012.01602.x
Publication History
- Issue published online: 29 OCT 2012
- Article first published online: 29 OCT 2012
- Accepted manuscript online: 14 JUL 2012 11:10AM EST
- Manuscript Accepted: 9 JUL 2012
- Manuscript Received: 3 APR 2012
Funded by
- Guy's & St. Thomas Charity
- National Institute for Health Research
References
- 1, , , et al. Short-term BMP-2 expression is sufficient for in vivo osteochondral differentiation of mesenchymal stem cells. Stem Cells. 2004; 22: 74–85. doi: 10.1634/stemcells.22-1-74.
- 2, , . Wnt signaling controls the fate of mesenchymal stem cells. Gene. 2009; 433: 1–7. doi: 10.1016/j.gene.2008.12.008.
- 3, , . Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development. 2002; 129: 5301–12.
- 4, , , et al. Adenosine receptor subtype expression and activation influence the differentiation of mesenchymal stem cells to osteoblasts and adipocytes. J Bone Miner Res. 2011; 26: 2112–24. doi: 10.1002/jbmr.424.
- 5, , , et al. Epidermal growth factor as a candidate for ex vivo expansion of bone marrow–derived mesenchymal stem cells. Stem Cells. 2006; 24: 686–95. doi: 10.1634/stemcells.2005-0176.
- 6, , , et al. Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF. Bioch Bioph Res Co. 2001; 288: 413–9. doi: 10.1006/bbrc.2001.5777.
- 7, , , et al. FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells. J Cell Physiol. 2005; 203: 398–409. doi: 10.1002/jcp.20238.
- 8, , , et al. Ex vivo enrichment of mesenchymal cell progenitors by fibroblast growth factor 2. Exp Cell Res. 2003; 287: 98–105. S0014482703001381 [pii]
- 9, , , et al. Role of c-Jun N-terminal kinase in the PDGF-induced proliferation and migration of human adipose tissue-derived mesenchymal stem cells. J Cell Biochem. 2005; 95: 1135–45. doi: 10.1002/jcb.20499.
- 10, , , et al. Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. Mech Ageing Dev. 2008; 129: 163–73. doi: 10.1016/j.mad.2007.12.002.
- 11, , , et al. Mesenchymal progenitor self-renewal deficiency leads to age-dependent osteoporosis in Sca-1/Ly-6A null mice. Proc Natl Acad Sci U S A. 2003; 100: 5840–5. doi: 10.1073/pnas.1036475100.
- 12, , , et al. Mesenchymal stem cells: flip side of the coin. Cancer Res. 2009; 69: 1255–8. doi: 10.1158/0008-5472.CAN-08-3562.
- 13, , , et al. Mesenchymal stem cell-based therapy: a new paradigm in regenerative medicine. J Cell Mol Med. 2009; 13: 4385–402. doi: 10.1111/j.1582-4934.2009.00857.x.
- 14, , , et al. PDGF receptor β is a potent regulator of mesenchymal stromal cell function. J Bone Miner Res. 2008; 23: 1519–28. doi: 10.1359/jbmr.080409.
- 15, , , et al. Platelet-derived growth factor (PDGF)–PDGF receptor interaction activates bone marrow–derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch. Blood. 2010; 116: 2984–93. doi: 10.1182/blood-2010-02-269894.
- 16, , , et al. Mesenchymal stem cell migration is regulated by fibronectin through α5β1-integrin-mediated activation of PDGFR-β and potentiation of growth factor signals. J Cell Sci. 2011; 124: 1288–300. doi: 10.1242/jcs.076935
- 17, , . Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008; 22: 1276–312. doi: 10.1101/gad.1653708.
- 18, , , et al. Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells. PLoS ONE. 2008; 3: e3794. doi: 10.1371/journal.pone.0003794.
- 19, , , et al. UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. J Biol Chem. 2008; 283: 30461–70. doi: 10.1074/jbc.M805400200.
- 20, , , et al. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PLoS ONE. 2009; 4: e6189. doi: 10.1371/journal.pone.0006189.
- 21, , . Evodiamine inhibits adipogenesis via the EGFR–PKCα–ERK signaling pathway. FEBS Lett. 2009; 583: 3655–9. doi: 10.1016/j.febslet.2009.10.046.
- 22, , , et al. Spata4 promotes osteoblast differentiation through Erk-activated Runx2 pathway. J Bone Miner Res. 2011; 26: 1964–73. doi: 10.1002/jbmr.394.
- 23, . Akt promotes BMP2-mediated osteoblast differentiation and bone development. J Cell Sci. 2009; 122: 716–26. doi: 10.1242/jcs.042770.
- 24, , , et al. Upregulation of PTEN in glioma cells by cord blood mesenchymal stem cells inhibits migration via downregulation of the PI3K/Akt pathway. PLoS ONE. 2010; 5: e10350. doi: 10.1371/journal.pone.0010350.
- 25, , , et al. Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): a prospective study aimed at identification of diagnostic and prognostic biomarkers as well as therapeutic targets. Ann Rheum Dis. 2012; 71: 415–23. doi: 10.1136/ard.2010.143529.
- 26, , . Akt signalling in health and disease. Cell Signal. 2011; 23: 1515–27. doi: 10.1016/j.cellsig.2011.05.004.
- 27. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer. 2009; 9: 550–62. doi: 10.1038/nrc2664.
- 28, , , et al. Contrasting effects of A1 and A2b adenosine receptors on adipogenesis. Int J Obes. 2012; 36: 397–406. doi: 10.1038/ijo.2011.129.
- 29, , , et al. PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR. J Clin Invest. 2007; 117: 730–8. doi: 10.1172/JCI28984.
- 30, , . Self-renewal and differentiation capacity of young and aged stem cells. Exp Cell Res. 2008; 314: 1937–44. doi: 10.1016/j.yexcr.2008.03.006.
- 31, , , et al. PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell. 2010; 17: 497–509. doi: 10.1016/j.ccr.2010.03.020.
- 32, , , et al. The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation. Genes Dev. 2010; 24: 683–95. doi: 10.1101/gad.560310.
- 33, . Manifestations and mechanisms of stem cell aging. J Cell Biol. 2011; 193: 257–66. doi: 10.1083/jcb.201010131.
- 34, , , et al. Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor-beta phosphorylation, and microvessel density in gastric cancer. BMC Cancer. 2010; 10: 659. doi: 10.1186/1471-2407-10-659.
- 35, , , et al. A novel signaling axis of atriptase/PDGF-D/β-PDGFR in human prostate cancer. Cancer Res. 2010; 70: 9631–40. doi: 10.1158/0008-5472.CAN-10-0511.
- 36, . Oncogenic protein tyrosine kinases: oncogenic derivatives of platelet-derived growth factor receptors. Cell Mol Life Sci. 2004; 61: 2912–23. doi: 10.1007/s00018-004-4272-z.
- 37, , . Autocrine fibroblast rowth Factor 2 signaling is critical for self-Renewal of human multipotent adipose-derived stem cells. Stem Cells. 2006; 24: 2412–9. doi: 10.1634/stemcells.2006-0006.
- 38, , , et al. Basic fibroblast growth factor stimulates the proliferation of human dermal fibroblasts via the ERK1/2 and JNK pathways. Br J Dermatol. 2010; 162: 717–23. doi: 10.1111/j.1365-2133.2009.09581.x.
- 39, , , et al. High dose human insulin and insulin glargine promote T24 bladder cancer cell proliferation via PI3K-independent activation of Akt. Diabetes Res Clin Pract. 2011; 91: 177–82. doi: 10.1016/j.diabres.2010.11.009.
- 40, , , et al. EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF. FASEB J. 2012; 26: 1582–92. doi: 10.1096/fj.11-194654.
- 41, , , et al. Fibroblast growth factor-2 and -4 promote the proliferation of bone marrow mesenchymal stem cells by the activation of the PI3K-Akt and ERK1/2 signaling pathways. Stem cells dev. 2008; 17: 725–36. doi: 10.1089/scd.2007.0230.
- 42, , , et al. Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non–small cell lung cancer cells in an epidermal rowth factor receptor–independent manner. Cancer Res. 2005; 65: 6275–81. doi: 10.1158/0008-5472.CAN-05-0216.
- 43, , , et al. Erk1/2 MAP kinases are required for epidermal G2/M progression. J Cell Biol. 2009; 185: 409–22. doi: 10.1083/jcb.200804038.
- 44, , , et al. PDGF signalling controls age-dependent proliferation in pancreatic β-cells. Nature. 2011; 478: 349–55. doi: 10.1038/nature10502.
- 45, , , et al. PYK2 signaling is required for PDGF-dependent vascular smooth muscle cell proliferation. Am J Physiol Cell Physiol. 2011; 301: C242–51. doi: 10.1152/ajpcell.00315.2010.
- 46, , . PI3K/Akt/mTOR pathway: a growth and proliferation pathway. In: Bukowski RM, Figlin RA, Motzer RJ, editors. Renal cell carcinoma. New York: Humana Press; 2009. pp. 267–85.
- 47, , , et al. Minireview: cyclin D1: normal and abnormal functions. Endocrinology. 2004; 145: 5439–47. doi: 10.1210/en.2004-0959.
- 48, . Targeting the mTOR signaling network for cancer therapy. J Clin Oncol. 2009; 27: 2278–87. doi: 10.1200/JCO.2008.20.0766.
- 49, , , et al. Tumor cell and connective tissue cell interactions in human colorectal adenocarcinoma. Transfer of platelet-derived growth factor-AB/BB to stromal cells. Am J Pathol. 1997; 151: 479–92.
- 50, , , et al. Serum regulates adipogenesis of mesenchymal stem cells via MEK/ERK-dependent PPARγ expression and phosphorylation. J Cell Mol Med. 2010; 14: 922–32. doi: 10.1111/j.1582-4934.2009.00709.x.
- 51, , , et al. Pigment epithelium-derived factor suppresses adipogenesis via inhibition of the MAPK/ERK pathway in 3T3-L1 preadipocytes. Am J Physiol Endocrinol Metab. 2009; 297: E1378–87. doi: 10.1152/ajpendo.00252.2009.
- 52, , , et al. Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation. Science. 2005; 308: 1472–7. doi: 10.1126/science.1107627.
- 53, , , et al. Platelet-derived growth factor receptor signaling is not involved in osteogenic differentiation of human mesenchymal stem cells. Tissue Eng Part A. 2009; 16: 983–93. doi: 10.1089/ten.TEA.2009.0230.